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Semin intervent Radiol 2003; 20(2): 111-124
DOI: 10.1055/s-2003-43316
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Venous Thromboembolism in Trauma

John G. Santilli
  • Vascular Radiologist, Division of Vascular Radiology, Massachusetts General Hospital, Boston, Massachusetts
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Publication History

Publication Date:
31 October 2003 (online)

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ABSTRACT

The rationale of thromboprophylaxis stems from the high incidence of venous thromboembolism (VTE) in hospitalized patients, the clinically silent nature of this entity in a vast majority of patients, and the morbidity and potential mortality that can often be associated with it. There are few specific symptoms associated with deep vein thrombosis (DVT) and VTE, thus making clinical diagnosis unreliable. Making appropriate diagnosis and implementing treatment of DVT prior to a potentially fatal embolic event or the potential sequelae and long-term morbidity of the postphlebitic syndrome is a difficult task in any hospitalized patient. In the setting of trauma, however, diagnosis, prevention, and treatment of DVT and VTE become much more difficult.

KEYWORDS

Venous thrombosis - coagulation - trauma

REFERENCES

  • 1 Napolitano L M, Garlapati V S, Heard S O. et al . Asymptomatic deep venous thrombosis in the trauma patient: is an aggressive screening protocol justified?.  J Trauma . 1995;  39 651-659
    PubMedGoogle Scholar
  • 2 Geerts W H, Code K I, Jay R M, Chen E, Szalai P. A prospective study of venous thromboembolism after major trauma [comments].  N Engl J Med . 1994;  331 1601-1606
    CrossrefPubMedGoogle Scholar
  • 3 Piotrowski J J, Alexander J J, Brandt C P, McHenry C R, Yuhas J P, Jacobs D. Is deep vein thrombosis surveillance warranted in high-risk trauma patients?.  Am J Surg . 1996;  172 210-213
    CrossrefPubMedGoogle Scholar
  • 4 Dennis J, Menawat W S, Von Thron J. et al . Efficacy of deep venous thrombosis prophylaxis in trauma patients and identification of high-risk groups.  J Trauma . 1993;  35 132-139
    CrossrefPubMedGoogle Scholar
  • 5 Greenfield L J, Proctor M C, Rodriguez J L, Luchette F A, Cipolle M C, Cho J. Post-trauma thromboembolism prophylaxis.  J Trauma . 1997;  42 100-103
    PubMedGoogle Scholar
  • 6 Headrick Jr R J, Barker D E, Pate L M, Horne K, Russell W L, Burns R P. The role of ultrasonography and inferior vena cava filter placement in high-risk trauma patients.  Am Surg . 1997;  63 1-8
    PubMedGoogle Scholar
  • 7 Spain D A, Richardson J D, Polk Jr C H, Bergamini T M, Wilson M A, Miller F B. Venous thromboembolism in the high-risk trauma patient: do risks justify aggressive screening and prophylaxis?.  J Trauma . 1997;  42 463-469
    CrossrefPubMedGoogle Scholar
  • 8 Brathwaite C E, O'Malley K F, Ross S E, Pappas P, Alexander J, Spence R K. Continuous pulse oximetry and the diagnosis of pulmonary embolism in critically ill trauma patients.  J Trauma . 1992;  33 528-531
    PubMedGoogle Scholar
  • 9 Coon W W. Risk factors in pulmonary embolism.  Surg Gynecol Obstet . 1976;  143 385-390
    PubMedGoogle Scholar
  • 10 Salzman E W, Hirsh J. The epidemiology, pathogenesis, and natural history of venous thrombosis. In: Colman RW, Hirsh J, Marder VJ, et al, eds. Hemostasis and Thrombosis, Basic Principles and Clinical Practice Philadelphia: Lippincott 1994: 1275-1296
    Google Scholar
  • 11 Flordal P A, Bergqvist D, Burmark U S, Ljungstrom K G, Torngren S. Risk factors for major thromboembolism and bleeding tendency after elective general surgical operations. The Fragmin Multicentre Study Group.  Eur J Surg . 1996;  162 783-789
    PubMedGoogle Scholar
  • 12 Sevitt S, Gallagher N. Venous thrombosis and pulmonary embolism: a clinico-pathological study on injured and burned patients.  Br J Surg . 1961;  48 475-489
    CrossrefPubMedGoogle Scholar
  • 13 Havig O. Deep vein thrombosis and pulmonary embolism. An autopsy study with multiple regression analysis of possible risk factors.  Acta Chir Scand Suppl . 1977;  478 1-120
    PubMedGoogle Scholar
  • 14 Saeger W, Genzkow M. Venous thromboses and pulmonary embolisms in post-mortem series: probable causes by correlations of clinical data and basic diseases.  Pathol Res Pract . 1994;  190 394-399
    PubMedGoogle Scholar
  • 15 Moser K M, LeMoine J R. Is embolic risk conditioned by location of deep venous thrombosis?.  Ann Intern Med . 1981;  94(4 pt 1) 439-444
    PubMedGoogle Scholar
  • 16 Hull R. Clinical Features of Deep Venous Thrombosis.  Armonk, NY: Futura Publishing 1996: 87-91
    Google Scholar
  • 17 Stein P. The Clinical Diagnosis of Acute Pulmonary Embolism.  Armonk, NY: Futura Publishing 1996: 161-167
    Google Scholar
  • 18 Franzeck U K, Schalch I, Jager K A, Schneider E, Frimm J, Bollinger A. Prospective 12-year follow-up study of clinical and hemodynamic sequelae after deep vein thrombosis in low-risk patients (Zurich study).  Circulation . 1996;  93 74-79
    PubMedGoogle Scholar
  • 19 Prandoni P, Lensing A W, Cogo A. et al . The long-term clinical course of acute deep venous thrombosis.  Ann Intern Med . 1996;  125 1-7
    CrossrefPubMedGoogle Scholar
  • 20 Knudson M M, Morabito D, Paiement G D, Schackleford S. Use of low molecular weight heparin in preventing thromboembolism in trauma patients.  J Trauma . 1996;  41 446-459
    PubMedGoogle Scholar
  • 21 Leach T A, Pastena J A, Swan K G, Tikellis J I, Blackwood J M, Odom J W. Surgical prophylaxis for pulmonary embolism.  Am Surg . 1994;  60 292-295
    PubMedGoogle Scholar
  • 22 Khansarinia S, Dennis J W, Veldenz H C, Butcher J L, Hartland L. Prophylactic Greenfield filter placement in selected high-risk trauma patients.  J Vasc Surg . 1995;  22 231-236
    CrossrefPubMedGoogle Scholar
  • 23 Burns G A, Cohn S M, Frumento R J, Degutis L C, Hammers L. Prospective ultrasound evaluation of venous thrombosis in high-risk trauma patients.  J Trauma . 1993;  35 405-408
    PubMedGoogle Scholar
  • 24 Rogers F B. Venous thromboembolism in trauma patients.  Surg Clin North Am . 1995;  75 279-291
    PubMedGoogle Scholar
  • 25 Rosenthal D, McKinsey J F, Levy A M, Lamis P A, Clark M D. Use of the Greenfield filter in patients with major trauma.  Cardiovasc Surg . 1994;  2 52-55
    PubMedGoogle Scholar
  • 26 Shackford S R, Davis J W, Hollingsworth-Fridlund P, Brewer N S, Hoyt D B, MacKersie R C. Venous thromboembolism in patients with major trauma.  Am J Surg . 1990;  159 365-369
    CrossrefPubMedGoogle Scholar
  • 27 Hull R D, Raskob G E, Rosenbloom D. Heparin for 5 days as compared with 10 days in the initial treatment of proximal venous thrombosis [comments].  N Engl J Med . 1990;  322 1260-1264
    PubMedGoogle Scholar
  • 28 Thomas 3rd O W, Ferrara J J, Rodning C B. A retrospective analysis of inferior vena caval filtration for prevention of pulmonary embolization.  Am Surg . 1988;  54 726-730
    PubMedGoogle Scholar
  • 29 Rodriguez J L, Lopez J M, Proctor M C. Early placement of prophylactic vena caval filters in injured patients at high risk for pulmonary embolism.  J Trauma . 1996;  40 797-804
    CrossrefPubMedGoogle Scholar
  • 30 Virchow R, Chance F (translator). Cellular Pathology. New York: Dewitt 1860
  • 31 Schaub R G, Lynch P R, Stewart G J. The response of canine veins to three types of abdominal surgery: a scanning and transmission electron microscopic study.  Surgery . 1978;  83 411-424
    PubMedGoogle Scholar
  • 32 Carvalho A, DeMarinis S M, Lynch K, Zapol W M. Antithrombin III in critically ill patients.  J Crit Care . 1989;  4 283-293
    CrossrefPubMedGoogle Scholar
  • 33 Enderson B L, Chen J P, Robinson R, Maull K I. Fibrinolysis in multisystem trauma patients.  J Trauma-Inj Infect Crit Care . 1991;  31 1240-1246
    PubMedGoogle Scholar
  • 34 Kapsch D N, Metzler M, Harrington M, Mitchell F L, Silver D. Fibrinolytic response to trauma.  Surgery . 1984;  95 473-478
    PubMedGoogle Scholar
  • 35 Miller R S, Weatherford D A, Stein D, Crane M M, Stein M. Antithrombin III and trauma patients: factors that determine low levels.  J Trauma-Inj Infect Crit Care . 1994;  37 442-445
    PubMedGoogle Scholar
  • 36 Buerger P M, Peoples J B, Lemmon G W, McCarthy M C. Risk of pulmonary emboli in patients with pelvic fractures.  Am Surg . 1993;  59 505-508
    PubMedGoogle Scholar
  • 37 Knudson M M, Collins J A, Goodman S D, McCrory D W. Thromboembolism following multiple trauma.  J Trauma-Inj Infect Crit Care . 1992;  32 2-11
    CrossrefPubMedGoogle Scholar
  • 38 Knudson M M, Lewis F R, Clinton A, Atkinson K, Megerman J. Prevention of venous thromboembolism in trauma patients.  J Trauma-Inj Infect Crit Care . 1994;  37 480-487
    PubMedGoogle Scholar
  • 39 Geerts W H, Jay R M, Code K I. A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma.  N Engl J Med . 1996;  335 701-707
    CrossrefPubMedGoogle Scholar
  • 40 Haentjens P. Thromboembolic prophylaxis in orthopaedic trauma patients: a comparison between a fixed dose and an individually adjusted dose of a low molecular weight heparin (nadroparin calcium).  Injury . 1996;  27 385-390
    CrossrefPubMedGoogle Scholar
  • 41 Kudsk K A, Fabian T C, Baum S, Gold R E, Mangiante E, Voeller G. Silent deep vein thrombosis in immobilized multiple trauma patients.  Am J Surg . 1989;  158 515-519
    CrossrefPubMedGoogle Scholar
  • 42 Ruiz A J, Hill S L, Berry R E. Heparin, deep venous thrombosis, and trauma patients.  Am J Surg . 1991;  162 159-162
    CrossrefPubMedGoogle Scholar
  • 43 Montgomery K D, Potter H G, Helfet D L. Magnetic resonance venography to evaluate the deep venous system of the pelvis in patients who have an acetabular fracture.  J Bone Joint Surg Am . 1995;  77 1639-1649
    PubMedGoogle Scholar
  • 44 Judet R, Judet J, Letournel E. Fractures of the acetabulum: classification and surgical approaches for open reductions.  J Bone Joint Surg Am . 1964;  46A 1615-1646
    PubMedGoogle Scholar
  • 45 Letournel E, Judet R. Fractures of the acetabulum.  New York: Springer 1993
    Google Scholar
  • 46 Webb L X, Rush P T, Fuller S B, Meredith J W. Greenfield filter prophylaxis of pulmonary embolism in patients undergoing surgery for acetabular fracture.  J Orthop Trauma . 1992;  6 139-145
    CrossrefPubMedGoogle Scholar
  • 47 Hull R, Delmore T, Genton E. Warfarin sodium versus low-dose heparin in the long-term treatment of venous thrombosis.  N Engl J Med . 1979;  301 855-858
    CrossrefPubMedGoogle Scholar
  • 48 Kakkar V V, Howe C T, Flanc C, Clarke M B. Natural history of postoperative deep-vein thrombosis.  Lancet . 1969;  2 230-232
    Google Scholar
  • 49 Tubiana R. Prevention of thrombo-embolic complications in orthopaedic and accident surgery.  J Bone Joint Surg Am . 1961;  43B 7-15
    PubMedGoogle Scholar
  • 50 Freeark R, Boswick J, Fardin R. Posttraumatic venous thrombosis.  Arch Surg . 1967;  95 567-575
    PubMedGoogle Scholar
  • 51 Kujath P, Spannagel U, Habscheid W. Incidence and prophylaxis of deep venous thrombosis in outpatients with injury of the lower limb.  Haemostasis . 1993;  23 20-26
    PubMedGoogle Scholar
  • 52 Poole G V, Ward E F, Griswold J A, Muakkassa F F, Hse H S. Complications of pelvic fractures from blunt trauma.  Am Surg . 1992;  58 225-231
    PubMedGoogle Scholar
  • 53 Lensing A W, Hirsh J. 125I-fibrinogen leg scanning: reassessment of its role for the diagnosis of venous thrombosis in post-operative patients.  Thromb Haemost . 1993;  69 2-7
    PubMedGoogle Scholar
  • 54 Agnelli G, Radicchia S, Nence G G. Diagnosis of deep vein thrombosis in asymptomatic high-risk patients.  Haemostasis . 1995;  25 40-48
    PubMedGoogle Scholar
  • 55 Flordal P A, Bergqvist D, Ljungstrom K G, Torngren S. Clinical relevance of the fibrinogen uptake test in patients undergoing elective general abdominal surgery-relation to major thromboembolism and mortality. Fragmin Multicentre Study Group.  Thromb Res . 1995;  80 491-497
    CrossrefPubMedGoogle Scholar
  • 56 Davidson B L, Elliott C G, Lensing A W. Low accuracy of color Doppler ultrasound in the detection of proximal leg vein thrombosis in asymptomatic high-risk patients. The RD Heparin Arthroplasty Group.  Ann Intern Med . 1992;  117 735-738
    PubMedGoogle Scholar
  • 57 Wells P S, Lensing A W, Davidson B L, Prins M H, Hirsh J. Accuracy of ultrasound for the diagnosis of deep venous thrombosis in asymptomatic patients after orthopedic surgery. A meta-analysis.  Ann Intern Med . 1995;  122 47-53
    PubMedGoogle Scholar
  • 58 Ciccone 2nd J W, Fox P S, Neumyer M, Rubens D, Parrish W M, Pelligrini Jr D V. Ultrasound surveillance for asymptomatic deep venous thrombosis after total joint replacement.  J Bone Joint Surg Am . 1998;  80 1167-1174
    PubMedGoogle Scholar
  • 59 Kearon C, Julian J A, Newman R E, Ginsberg J S. Noninvasive diagnosis of deep venous thrombosis. McMaster Diagnostic Imaging Practice Guidelines Initiative.  Ann Intern Med . 1998;  128 663-677
    Google Scholar
  • 60 Hull R D, Raskob G E, Hirsh J. Continuous intravenous heparin compared with intermittent subcutaneous heparin in the initial treatment of proximal-vein thrombosis.  N Engl J Med . 1986;  315 1109-1114
    CrossrefPubMedGoogle Scholar
  • 61 White R H, Goulet J A, Bray T J, Daschbach M M, McGahan J P, Hartling R P. Deep-vein thrombosis after fracture of the pelvis: assessment with serial duplex-ultrasound screening.  J Bone Joint Surg Am . 1990;  72 495-500
    PubMedGoogle Scholar
  • 62 Lensing A W, Prandoni P, Brandjes D. Detection of deep-vein thrombosis by real-time B-mode ultrasonography [comments].  N Engl J Med . 1989;  320 342-345
    Google Scholar
  • 63 Greenfield L J. Venous thrombosis and pulmonary embolism.  Philadelphia: Lippincott 1993
    Google Scholar
  • 64 Carpenter J P, Holland G A, Baum R A, Owen R S, Carpenter J T, Cope C. Magnetic resonance venography for the detection of deep venous thrombosis: comparison with contrast venography and duplex Doppler ultrasonography.  J Vasc Surg . 1993;  18 734-741
    CrossrefPubMedGoogle Scholar
  • 65 Erdman W A, Weinreb J C, Cohen J M, Buja L M, Chaney C, Peshock R M. Venous thrombosis: clinical and experimental MR imaging.  Radiology . 1986;  161 233-238
    PubMedGoogle Scholar
  • 66 Erdman W A, Jayson H T, Redman H C, Miller G L, Parkey R W, Peshock R W. Deep venous thrombosis of extremities: role of MR imaging in the diagnosis.  Radiology . 1990;  174 425-431
    CrossrefPubMedGoogle Scholar
  • 67 Evans A J, Sostman H D, Witty L A. et al . Detection of deep venous thrombosis: prospective comparison of MR imaging and sonography.  J Magn Reson Imaging . 1996;  6 44-51
    PubMedGoogle Scholar
  • 68 Rapoport S, Sostman H D, Pope C, Camputaro C M, Holcomb W, Gore J C. Venous clots: evaluation with MR imaging.  Radiology . 1987;  162 527-530
    PubMedGoogle Scholar
  • 69 Spritzer C E, Norconk Jr J J, Sostman H D, Coleman R E. Detection of deep venous thrombosis by magnetic resonance imaging.  Chest . 1993;  104 54-60
    Google Scholar
  • 70 Stern J B, Abehsera M, Grenit D. et al . Detection of pelvic vein thrombosis by magnetic resonance angiography in patients with acute pulmonary embolism and normal lower limb compression ultrasonography.  Chest . 2002;  122 115-121
    CrossrefPubMedGoogle Scholar
  • 71 Bauer G. Thrombosis following leg injuries.  Acta Chir Scand . 1944;  90 229-248
    PubMedGoogle Scholar
  • 72 Velmahos G C, Kern J, Chan L S, Oder D, Murray J A, Shekelle P. Prevention of venous thromboembolism after injury: an evidence-based report-part I: analysis of risk factors and evaluation of the role of vena caval filters.  J Trauma . 2000;  49 132-139
    CrossrefPubMedGoogle Scholar
  • 73 Clagett G P, Reisch J S. Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis.  Ann Surg . 1988;  208 227-240
    CrossrefPubMedGoogle Scholar
  • 74 Butson A R. Intermittent pneumatic calf compression for prevention of deep venous thrombosis in general abdominal surgery.  Am J Surg . 1981;  142 525-527
    CrossrefPubMedGoogle Scholar
  • 75 Hills N H, Pflug J J, Jeyasingh K, Boardman L, Calnan J S. Prevention of deep vein thrombosis by intermittent pneumatic compression of calf.  Br Med J . 1972;  1 131-135
    PubMedGoogle Scholar
  • 76 Wells P S, Lensing A W, Hirsh J. Graduated compression stockings in the prevention of postoperative venous thromboembolism. A meta-analysis [comments].  Arch Intern Med . 1994;  154 67-72
    CrossrefPubMedGoogle Scholar
  • 77 Moser G, Krahenbuhl B, Barroussel R, Bene J J, Donath A, Rohner A. Mechanical versus pharmacologic prevention of deep venous thrombosis.  Surg Gynecol Obstet . 1981;  152 448-450
    PubMedGoogle Scholar
  • 78 Nicolaides A N, Miles C, Hoare M, Jury P, Helmis E, Venniker R. Intermittent sequential pneumatic compression of the legs and thromboembolism-deterrent stockings in the prevention of postoperative deep venous thrombosis.  Surgery . 1983;  94 21-25
    PubMedGoogle Scholar
  • 79 Muhe E. Intermittent sequential high-pressure compression of the leg. A new method of preventing deep vein thrombosis.  Am J Surg . 1984;  147 781-785
    CrossrefPubMedGoogle Scholar
  • 80 Montrey J S, Kistner R L, Kong A V. et al . Thromboembolism following hip fracture.  J Trauma . 1985;  25 534-537
    PubMedGoogle Scholar
  • 81 Gersin K, Grindlinger G A, Lee V, Dennis R C, Wedel S K, Cachecho R. The efficacy of sequential compression devices in multiple trauma patients with severe head injury.  J Trauma . 1994;  37 205-208
    PubMedGoogle Scholar
  • 82 Wille-Jorgensen P, Thorup J, Fischer A, Holst-Christensen J, Flamsholt R. Heparin with and without graded compression stockings in the prevention of thromboembolic complications of major abdominal surgery: a randomized trial.  Br J Surg . 1985;  72 579-581
    PubMedGoogle Scholar
  • 83 Torngren S. Low dose heparin and compression stockings in the prevention of postoperative deep venous thrombosis.  Br J Surg . 1980;  67 482-484
    PubMedGoogle Scholar
  • 84 Fisher C G, Blachut P A, Salvian A J, Meek R N, O'Brien P J. Effectiveness of pneumatic leg compression devices for the prevention of thromboembolic disease in orthopaedic trauma patients: a prospective, randomized study of compression alone versus no prophylaxis.  J Orthop Trauma . 1995;  9 1-7
    PubMedGoogle Scholar
  • 85 Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery.  N Engl J Med . 1988;  318 1162-1173
    CrossrefPubMedGoogle Scholar
  • 86 Nurmohamed M T, Rosendaal F R, Buller H R. et al . Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis.  Lancet . 1992;  340 152-156
    CrossrefPubMedGoogle Scholar
  • 87 Jorgensen L N, Wille-Jorgensen P, Hauch O. et al . Prophylaxis of postoperative thromboembolism with low molecular weight heparins.  Br J Surg . 1993;  80 689-704
    PubMedGoogle Scholar
  • 88 Koch A, Bouges S, Ziegler S, Dinkel H, Daures J P, Victor N. Low molecular weight heparin and unfractionated heparin in thrombosis prophylaxis after major surgical intervention: update of previous meta-analyses.  Br J Surg . 1997;  84 750-759
    CrossrefPubMedGoogle Scholar
  • 89 Thomas D P. Does low molecular weight heparin cause less bleeding?.  Thromb Haemost . 1997;  78 1422-1425
    PubMedGoogle Scholar
  • 90 Green D, Lee M Y, Lim A C. et al . Prevention of thromboembolism after spinal cord injury using low-molecular-weight heparin [comments].  Ann Intern Med . 1997;  113 571-574
    PubMedGoogle Scholar
  • 91 Green D, Chen D, Chmiel J S. et al . Prevention of thromboembolism in spinal cord injury: role of low molecular weight heparin.  Arch Phys Med Rehab . 1994;  75 290-292
    CrossrefPubMedGoogle Scholar
  • 92 Imperiale T F, Speroff T. A meta-analysis of methods to prevent venous thromboembolism following total hip replacement [comments] [erratum appears in JAMA 1995;273: 288].  JAMA . 1994;  271 1780-1785
    CrossrefPubMedGoogle Scholar
  • 93 Lieberman J R, Geerts W H. Prevention of venous thromboembolism after total hip and knee arthroplasty.  J Bone Joint Surg Am . 1994;  76 1239-1250
    PubMedGoogle Scholar
  • 94 Mohr D N, Silverstein M D, Murtaugh P A, Harrison J M. Prophylactic agents for venous thrombosis in elective hip surgery. Meta-analysis of studies using venographic assessment [comments].  Arch Intern Med . 1993;  153 2221-2228
    CrossrefPubMedGoogle Scholar
  • 95 Kock H J, Schmit-Neuerburg K P, Hanke J, Rudofsky G, Hirche H. Thromboprophylaxis with low-molecular-weight heparin in outpatients with plaster-cast immobilisation of the leg.  Lancet . 1995;  346 459-461
    CrossrefPubMedGoogle Scholar
  • 96 Hirsh J, Warkentin T E, Raschke R, Granger C, Ohman E M, Dalen J E. Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety.  Chest . 1998;  114(Suppl 5) 489S-510S
    PubMedGoogle Scholar
  • 97 Warkentin T E, Levine M N, Hirsh J. et al . Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin.  N Engl J Med . 1995;  332 1330-1335
    CrossrefPubMedGoogle Scholar
  • 98 Dismuke S E, Wagner E H. Pulmonary embolism as a cause of death. The changing mortality in hospitalized patients.  JAMA . 1986;  255 2039-2042
    CrossrefPubMedGoogle Scholar
  • 99 Lilienfeld D E, Chan E, Ehland J, Godbold J H, Landrigan P H, Marsh G. Mortality from pulmonary embolism in the United States: 1962 to 1984.  Chest . 1990;  98 1067-1072
    PubMedGoogle Scholar
  • 100 Rasmussen M S, Wille-Jorgensen P, Jorgensen L N. Postoperative fatal pulmonary embolism in a general surgical department.  Am J Surg . 1995;  169 214-216
    CrossrefPubMedGoogle Scholar
  • 101 Stratton M A, Anderson F A, Bussey H I. et al . Prevention of venous thromboembolism: adherence to the 1995 American College of Chest Physicians consensus guidelines for surgical patients.  Arch Intern Med . 2000;  160 334-340
    CrossrefPubMedGoogle Scholar
  • 102 Silverstein M D, Heit J A, Mohr D N, Petterson T M, O'Fallon W M, Melton 3rd J L. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study.  Arch Intern Med . 1998;  158 585-593
    CrossrefPubMedGoogle Scholar
  • 103 Hansson P O, Welin L, Tibblin G, Eriksson H. Deep vein thrombosis and pulmonary embolism in the general population. "The Study of Men Born in 1913." Arch Intern Med .  1997;  157 1665-1670
    CrossrefPubMedGoogle Scholar
  • 104 Rogers F B, Shackford S R, Wilson J, Ricci M A, Morris C S. Prophylactic vena cava filter insertion in severely injured trauma patients: indications and preliminary results.  J Trauma . 1993;  35 637-642
    PubMedGoogle Scholar
  • 105 Rogers F B, Shackford S R, Ricci M A, Wilson J T, Parsons S. Routine prophylactic vena cava filter insertion in severely injured trauma patients decreases the incidence of pulmonary embolism.  J Am Coll Surg . 1995;  180 641-647
    PubMedGoogle Scholar
  • 106 Langan 3rd M E, Miller R S, Casey 3rd J W, Graham M R, Taylor S M. Prophylactic inferior vena cava filters in trauma patients at high risk: follow-up examination and risk/benefit assessment.  J Vasc Surg . 1999;  30 484-488
    CrossrefPubMedGoogle Scholar
  • 107 Myllynen P, Kammonen M, Rokkanen P, Bostman D, Lalla M, Laasonen E. Deep venous thrombosis and pulmonary embolism in patients with acute spinal cord injury: a comparison with nonparalyzed patients immobilized due to spinal fractures.  J Trauma . 1985;  25 541-543
    CrossrefPubMedGoogle Scholar
  • 108 Todd J W, Frisbie J H, Rossier A B. et al . Deep venous thrombosis in acute spinal cord injury: a comparison of 125I fibrinogen leg scanning, impedance plethysmography and venography.  Paraplegia . 1976;  14 50-57
    CrossrefPubMedGoogle Scholar
  • 109 Brach B B, Moser K M, Cedar L, Minteer M, Convery R. Venous thrombosis in acute spinal cord paralysis.  J Trauma . 1977;  17 289-292
    PubMedGoogle Scholar
  • 110 Cohen J R, Grella L, Citron M. Greenfield filter instead of heparin as primary treatment for deep venous thrombosis or pulmonary embolism in patients with cancer.  Cancer . 1992;  70 1993-1996
    PubMedGoogle Scholar
  • 111 Jarrell B E, Posuniak E, Roberts J, Osterholm J, Cotter J, Ditunno J. A new method of management using the Kim-Ray Greenfield filter for deep venous thrombosis and pulmonary embolism in spinal cord injury.  Surg Gynecol Obstet . 1983;  157 316-320
    PubMedGoogle Scholar
  • 112 Winchell R J, Hoyt D B, Walsh J C, Simons R K, Eastman A B. Risk factors associated with pulmonary embolism despite routine prophylaxis: implications for improved protection.  J Trauma . 1994;  37 600-606
    CrossrefPubMedGoogle Scholar
  • 113 Rogers F B, Strindberg G, Shackford S R. et al . Five-year follow-up of prophylactic vena cava filters in high-risk trauma patients.  Arch Surg . 1998;  133 406-412
    CrossrefPubMedGoogle Scholar
  • 114 Matous S, Puyana J, Castle J M. The use of inferior vena cava filter in trauma patients. Paper presented at 24th Annual Scientific Meeting of the Western Trauma Association; 1995; Big Sky, Montana
    Google Scholar
  • 115 Erstad B L. Venous thromboembolism in multiple trauma patients.  Pharmacotherapy . 1998;  18 1011-1023
    PubMedGoogle Scholar
  • 116 Gosin J S, Graham A M, Cicco R G, Hammond J S. Efficacy of prophylactic vena cava filters in high-risk trauma patients.  Ann Vasc Surg . 1997;  11 100-105
    CrossrefPubMedGoogle Scholar
  • 117 Patton Jr H J, Fabian T C, Croce M A, Minard G, Pritchard F E, Kudsk K A. Prophylactic Greenfield filters: acute complications and long-term follow-up.  J Trauma . 1996;  41 231-236
    PubMedGoogle Scholar
  • 118 Sue L P, Davis J W, Parks S N. Iliofemoral venous injuries: an indication for prophylactic caval filter placement.  J Trauma . 1995;  39 693-695
    PubMedGoogle Scholar
  • 119 Carlin A M, Tyburski J G, Wilson R F, Steffes C. Prophylactic and therapeutic inferior vena cava filters to prevent pulmonary emboli in trauma patients.  Arch Surg . 2002;  137 521-527
    CrossrefPubMedGoogle Scholar
  • 120 Decousus H, Leizorovicz A, Parent F. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. Prevention du Risque d'Embolie Pulmonaire par Interruption Cave Study Group.  N Engl J Med . 1998;  338 409-415
    CrossrefPubMedGoogle Scholar
  • 121 Blebea J, Wilson R, Waybill P. et al . Deep venous thrombosis after percutaneous insertion of vena caval filters.  J Vasc Surg . 1999;  30 821-828
    PubMedGoogle Scholar
  • 122 Becker D M, Philbrick J T, Selby J B. Inferior vena cava filters. Indications, safety, effectiveness.  Arch Intern Med . 1992;  152 1985-1994
    CrossrefPubMedGoogle Scholar
  • 123 Rohrer M, Schneidler M, Wheeler H B, Cutler B S. Extended indications for placement of an inferior vena cava filter.  J Vasc Surg . 1989;  10 44-50
    CrossrefPubMedGoogle Scholar
  • 124 McMurtry A, Owings J T, Anderson J T, Battistella F D, Gosselin R. Increased use of prophylactic inferior vena cava filters in trauma patients failed to decrease overall incidence of pulmonary embolism.  J Am Coll Surg . 1999;  189 314-320
    CrossrefPubMedGoogle Scholar
  • 125 Boyd-Kranis R, Sullivan K L, Eschelman D J, Bonn J, Gardiner G A. Accuracy and safety of carbon dioxide inferior vena cavography.  J Vasc Interv Radiol . 1999;  10 1183-1189
    PubMedGoogle Scholar
  • 126 Kaufman J, Geller S, Bazari H, Waltman A C. Gadolinium-based contrast agents as an alternative at vena cavography in patients with renal insufficiency-early experience.  Radiology . 1999;  212 280-284
    PubMedGoogle Scholar
  • 127 Ashley D W, Gamblin T C, Burch S T, Solis M M. Accurate deployment of vena cava filters: comparison of intravascular ultrasound and contrast venography.  J Trauma . 2001;  50 975-981
    CrossrefPubMedGoogle Scholar
  • 128 Sing R F, Cicci C K, Smith C H, Messick W J. Bedside insertion of inferior vena cava filters in the intensive care unit.  J Trauma . 1999;  47 1104-1107
    PubMedGoogle Scholar
  • 129 Benjamin M E, Sandager G P, Cohn Jr J E. et al . Duplex ultrasound insertion of inferior vena cava filters in multitrauma patients.  Am J Surg . 1999;  178 92-97
    CrossrefPubMedGoogle Scholar
  • 130 Nunn C R, Neuzil D, Naslund T. et al . Cost-effective method for bedside insertion of vena caval filters in trauma patients.  J Trauma . 1977;  43 752-758
    PubMedGoogle Scholar
  • 131 Neuzil D, Garrard C, Berkman R A, Pierce R, Naslund T C. Duplex-directed vena caval filter placement: report of initial experience.  Surgery . 1998;  123 470-474
    CrossrefPubMedGoogle Scholar
  • 132 Sato D T, Robinson K D, Gregory R T. et al . Duplex directed caval filter insertion in multi-trauma and critically ill patients.  Ann Vasc Surg . 1999;  13 365-371
    CrossrefPubMedGoogle Scholar
  • 133 Zwaan M, Lorch H, Kulke C. et al . Clinical experience with temporary vena caval filters.  J Vasc Interv Radiol . 1998;  9 594-601
    PubMedGoogle Scholar
  • 134 Millward S F, Bhargava A, Aquino Jr J. et al . Gunther Tulip filter: preliminary clinical experience with retrieval.  J Vasc Interv Radiol . 2000;  11 75-82
    PubMedGoogle Scholar
  • 135 Millward S F. Gunther Tulip retrievable filter: why, when and how?.  Can Assoc Radiol J . 2001;  52 188-192
    PubMedGoogle Scholar
  • 136 Millward S F, Oliva V L, Bell S D. et al . Gunther Tulip retrievable vena cava filter: results from the Registry of the Canadian Interventional Radiology Association.  J Vasc Interv Radiol . 2001;  12 1053-1058
    CrossrefPubMedGoogle Scholar
  • 137 Neuerburg J M, Gunther R W, Vorwerk D. et al . Results of a multicenter study of the retrievable Tulip vena cava filter: early clinical experience.  Cardiovasc Intervent Radiol . 1997;  20 10-16
    CrossrefPubMedGoogle Scholar
  • 138 Neuerburg J M, Handt S, Beckert K. et al . Percutaneous retrieval of the Tulip vena cava filter: feasibility, short- and long-term changes-an experimental study in dogs.  Cardiovasc Intervent Radiol . 2001;  24 418-423
    CrossrefPubMedGoogle Scholar
  • 139 Neuerburg J M, Gunther R W, Rasmussen E. et al . New retrievable percutaneous vena cava filter: experimental in vitro and in vivo evaluation.  Cardiovasc Intervent Radiol . 1993;  16 224-229
    CrossrefPubMedGoogle Scholar
  • 140 Geerts W H, Heit J A, Clagett G P. et al . Prevention of venous thromboembolism.  Chest . 2001;  119 132S-175S
    CrossrefPubMedGoogle Scholar
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