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Synlett 2004(1): 69-72
DOI: 10.1055/s-2003-43379
DOI: 10.1055/s-2003-43379
LETTER
© Georg Thieme Verlag Stuttgart · New York
A New Regioselective Synthesis of Vicinal Bromohydrins via Free Radical Decarboxylative Bromination of β-Hydroxycarboxylic Acids
Weitere Informationen
Received
24 October 2003
Publikationsdatum:
04. Dezember 2003 (online)
Publikationsverlauf
Publikationsdatum:
04. Dezember 2003 (online)
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Abstract
Diisopropylcarbodiimide-mediated condensations between N-hydroxypyridine-2(1H)-thione and β-hydroxycarboxylic acids afforded mixed anhydrides which were regioselectively converted into vicinal bromohydrins under neutral conditions.
Key words
1,2-bromohydrin - bromination - carbon radical - pyridinethione - stereoselective synthesis
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