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Horm Metab Res 2003; 35(10): 565-569
DOI: 10.1055/s-2003-43500
Original Basic
© Georg Thieme Verlag Stuttgart · New York

Increased Activity of Glycerol 3-phosphate Dehydrogenase and Other Lipogenic Enzymes in Human Bladder Cancer

J.  Turyn1 , B.  Schlichtholz1 , A.  Dettlaff-Pokora1 , M.  Presler1 , E.  Goyke1 , M.  Matuszewski2 , Z.  Kmieć3 , K.  Krajka2 , J.  Swierczynski1
  • 1Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
  • 2Department of Urology, Medical University of Gdansk, Gdansk, Poland
  • 3Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
Further Information

Publication History

Received 3 February 2003

Accepted after second revision 14 July 2003

Publication Date:
07 November 2003 (online)

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Abstract

Common molecular changes in cancer cells are high carbon flux through the glycolytic pathway and overexpression of fatty acid synthase, a key lipogenic enzyme. Since glycerol 3-phosphate dehydrogenase creates a link between carbohydrates and the lipid metabolism, we have investigated the activity of glycerol 3-phosphate dehydrogenase and various lipogenic enzymes in human bladder cancer.

The data presented in this paper indicate that glycerol 3-phosphate dehydrogenase activity in human bladder cancer is significantly higher compared to adjacent non-neoplastic tissue, serving as normal control bladder tissue. Increased glycerol 3-phosphate dehydrogenase activity is accompanied by increased enzyme activity, either directly (fatty acid synthase) or indirectly (through ATP-citrate lyase, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and citrate synthase) involved in fatty acid synthesis. Coordinated upregulation of glycerol 3-phosphate dehydrogenase and lipogenic enzymes activities in human bladder cancer suggests that glycerol 3-phosphate dehydrogenase supplies glycerol 3-phosphate for lipid biosynthesis.

Key words

Glycerol 3-phosphate dehydrogenase - Lipogenic enzymes - Bladder cancer

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J. Swierczynski, M. D., Ph. D. 

Department of Biochemistry · Medical University of Gdansk

ul. Debinki 1 · 80-211 Gdansk · Poland

Fax: +48 (58) 349 14 65

Email: juls@amg.gda.pl