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Semin Thromb Hemost 2003; 29(5): 459-466
DOI: 10.1055/s-2003-44553
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Hyperviscosity as a Complication in a Variety of Disorders

Michael W. Rampling
  • Imperial College School of Medicine, South Kensington, London, United Kingdom
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Publication History

Publication Date:
21 November 2003 (online)

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ABSTRACT

For a considerable time, hyperviscosity syndrome has been widely recognized as a serious manifestation of polycythemia and plasma cell dyscrasia. In this article a number of conditions will be considered in which the association with hyperviscosity has been more recently recognized and is less widely known. These conditions are hyperleukocytosis, retinoic acid therapy, and connective tissue disease such as rheumatoid arthritis. The essential problems in the first two are the hugely elevated white cell count (WCC) and the mechanical properties of the leukocytes, in other words, their relatively poor deformability and their adhesiveness for the endothelium. In the last, the essential problem is hugely elevated plasma viscosity due to immunocomplexes. They lead to increased flow resistance, especially in the microvessels, abnormal flow, and significant clinical symptoms. The details of the causes of the hyperviscosity, the symptoms that result, and the forms of treatment are discussed.

KEYWORDS

Hyperleukocytosis - hyperviscosity - leukostasis - retinoic acid - rheumatoid arthritis

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