Experimentelle Untersuchungen zu De- und Remineralisationsprozessen im Wurzeldentin

Zusammenfassung

Um neue Kenntnisse zu Genese und Histopathologie, zur präventiven und therapeutischen Beeinflussbarkeit der Karies zu gewinnen, ist es notwendig, die initialkariösen Prozesse unter In-vitro-Bedingungen zu simulieren und den Einfluss verschiedener Faktoren auf die De- und Remineralisationsvorgänge aufzuzeigen. Die Erzeugung artifizieller kariöser Läsionen sowohl im Schmelz als auch im Dentin erfolgt dabei mit experimentellen Ansätzen und unterschiedlichen Aufgabenstellungen.

Summary

Fluoride application during artificial caries formation results in smaller lesions compared to the controls and a distinct remineralization within the lesions. There were no differences concerning this caries inhibiting effect between the toothpastes used (1400 ppm F- as SnF2/AmF, AmF or NaF). The cementum layer influenced the diffusion processes at the root surface. The combination of polarized light microscopy and X-ray microanalysis is a suitable model for studying de- and remineralization processes in bulk samples as well as in tooth sections.

De- und Remineralisation - Zement - Dentin - Zahnpasten - Fluoride

De- and Remineralization - Cementum - Dentin - Toothpastes - Fluorides

Literatur

• 1 Arends J, Ruben JL, Christoffersen J, Jongebloed WL, Zuidgeest TGM. Remineralization of human dentine in vitro.  Caries Res. 1990;  24 432-435
• 2 Beier M, Kraft U, Dietz W, Glockmann E, Hoyer I. Investigation of remineralization in dentin using a tooth section model.  J Dent Res. 2000;  79 388
• 3 Damen JJM, Buijs MJ, ten JM Cate. Fluoride-dependent formation of mineralized layers in bovine dentin during demineralization in vitro.  Caries Res. 1998;  32 435-440
• 4 Dietz W, Kraft U, Hoyer I. Untersuchung von Mineralisationsprozessen bei experimenteller Wurzelkaries.  Europ J Cell biol. 1997;  74 106
• 5 Dietz W, Kraft U, Hoyer I, Klingberg G. Influence of cementum on the demineralization and remineralization processes of root surface caries in vitro.  Acta Odontol Scand. 2002;  60 241-247
• 6 Gängler P, Noren JG, Hoyer I. et al. . Reactivity of young and old human enamel to demineralization.  Scand J Dent Res. 1993;  101 345-349
• 7 Heilmann JR, Jordan TH, Warwick R, Wefel JS. Remineralization of root surfaces demineralized in solutions of differing fluoride levels.  Caries Res. 1997;  31 423-428
• 8 Kawasaki K, Ruben J, Tsuda H, Huysmans MCDNJM, Tagaki O. Relationship between mineral distributions in dentine lesions and subsequent remineralization in vitro.  Caries Res. 2000;  34 395-403
• 9 Kraft U, Dietz W, Hoyer I. Investigation of mineralization processes in artificial root caries lesions.  Caries Res. 1997;  31 301
• 10 Kraft U, Beier M, Dietz W, Hoyer I, Glockmann E. Investigation of demineralization in natural root surfaces using a tooth section model.  Caries Res. 2000;  34 333
• 11 McIntyre JM, Featherstone JD, Fu J. Studies of dental root surface caries. 2: The role of cementum in root surface caries.  Aust Dent J. 2000;  45 97-102
• 12 Phankosol P, Ettinger RL, Hicks MJ, Wefel JS. Histopathology of the initial lesion of the root surface: An in vitro study.  J Dent Res. 1985;  64 804-809
• 13 Ruben J, Arends J. Shrinkage prevention of in vitro demineralized human dentine in transversal microradiography.  Caries Res. 1993;  27 266-270
• 14 Ten JM Cate. Review on fluoride, with special emphasis on calcium fluoride mechanisms in caries prevention.  Eur J Oral Sci. 1997;  105 461-465
• 15 Ten JM Cate, Damen JJM, Buijs MJ. Inhibition of dentin demineralization by fluoride in vitro.  Caries Res. 1998;  32 141-147
• 16 Wefel JS, Heilmann JR, Jordan TH. Comparison of in vitro root caries models.  Caries Res. 1995;  29 204-209

Korrespondenzadresse