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Planta Med 2003; 69(10): 967-970
DOI: 10.1055/s-2003-45113
Letter
© Georg Thieme Verlag Stuttgart · New York

Two New Benzofuranes from Eupatorium aschenbornianum and their Antimicrobial Activity

María Yolanda Rios1 , A. Berenice Aguilar-Guadarrama1 , Victor Navarro2
  • 1Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México
  • 2Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, México
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Publikationsverlauf

Received: April 8, 2003

Accepted: July 12, 2003

Publikationsdatum:
02. Dezember 2003 (online)

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Erratum zu diesem Artikel:

Two New Benzofurans from Eupatorium aschenbornianum and their Antimicrobial ActivityPlanta Med 2004; 70(04): 384-384
DOI: 10.1055/s-2004-818984

Abstract

Through a bioassay-guided fractionation, from the aerial parts of the medicinal plant Eupatorium aschenbornianum were isolated two new benzofurane compounds, 5-acetyl-3β-angeloyloxy-2β-(1-hydroxyisopropyl)-2,3-dihydrobenzofurane (1) and 5-acetyl-3β-angeloyloxy-2β-(1-hydroxyisopropyl)-6-methoxy-2,3-dihydrobenzofurane (2) in addition to 4-hydroxy-3,5-diprenylacetophenone, espeletone (3), encecalinol (4), β-sitosterol and stigmasterol. The antimicrobial evaluation of these natural products showed that 1 [MIC = 200 μg/mL against T. mentagrophytes and 100 μg/mL against T. rubrum], 2 [MIC = 50 μg/mL towards both] and 3 [MIC = 100 μg/mL against both] were active against dermatophytes, while 4 was active against all of microorganisms assayed [MIC = 12.5 μg/mL (T. mentagrophytes), 12.5 μg/mL (T. rubrum), 100 μg/mL (C. albicans) and 200 μg/mL (A. niger)].

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Dr. María Yolanda Rios

Centro de Investigaciones Químicas

Universidad Autónoma del Estado de Morelos

Av. Universidad 1001

Chamilpa 62210

Cuernavaca Mor.

México

Fax: +52-777-329-7997

eMail: myolanda@buzon.uaem.mx