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DOI: 10.1055/s-2003-45143
© Georg Thieme Verlag Stuttgart · New York
The Chalcone Butein from Rhus verniciflua shows Antifibrogenic Activity
This research was supported by a grant (#PF320401-00) from the Plant Diversity Research Center of 21st Century Frontier Research Program funded by the Ministry of Science and Technology of the Korean Government and by Spela Co., Ltd.Publication History
Received: May 9, 2003
Accepted: July 26, 2003
Publication Date:
09 January 2004 (online)
Abstract
Butein is known to be the major component of the bark of Rhus verniciflua Stokes (Anacardiaceae). The aim of this work was to investigate the effects of butein on liver fibrosis induced by carbon tetrachloride (CCl4) in rats, and to explore its antifibrogenic mechanism. Butein (10 mg/kg/day or 25 mg/kg/day) showed a significant reduction of hydroxyproline and malondialdehyde levels in rats. The expression of α1(I) collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNAs in liver was clearly reduced in a dose-dependent manner in rats given butein compared with control CCl4-treated rats. These data suggest the potential of butein to serve as an antifibrogenic agent by inhibition of collagen accumulation and lipid peroxidation, and by down-regulation of the expression of both α1(I) collagen and TIMP-1 mRNA.
Abbreviations
ALT:alanine aminotransferase
AST:aspartate aminotransferase
CCl4:carbon tetrachloride
ECM:extracellular matrix
TBARS:thiobarbituric acid reactive substance
TIMP-1:tissue inhibitor of metalloproteinase-1
Key words
Antifibrogenic activity - butein - carbon tetrachloride - α1(I) collagen - tissue inhibitor of metalloproteinase-1 - Rhus verniciflua - Anacardiaceae
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Prof. Dong Hwan Sohn
College of Pharmacy
Wonkwang University
Iksan
Chonbuk 570-749
Republic of Korea
Phone: +82-63-850-6822
Fax: +82-63-854-6038
Email: dhsohn@wonkwang.ac.kr