Planta Med 2003; 69(11): 1001-1004
DOI: 10.1055/s-2003-45145
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antinociceptive Effects of Ginsenosides Injected Intracerebroventricularly or Intrathecally in Substance P-Induced Pain Model

Seong-Soo Choi1 , Eun-Jung Han1 , Ki-Jung Han1 , Han-Kyu Lee1 , Hong-Won Suh1
  • 1Department of Pharmacology, College of Medicine and Institute of Natural Medicine, Hallym University, Kangwondo, South Korea
This work was supported by the Research Grant from Hallym University, South Korea
Further Information

Publication History

Received: April 8, 2003

Accepted: August 24, 2003

Publication Date:
09 January 2004 (online)

Abstract

We have examined the effects of several ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1 and Rg3) adminstered intracerebroventricularly (i. c. v.) or intrathecally (i. t.) on the nociceptive behavior induced by substance P (0.7 μg) injected i. t. Among the several ginsenosides studied, Rb2, Rc, Rd, and Re, but not Rb1, Rf, Rg1 and Rg3, treated i. c. v. (50 μg) attenuated the nociceptive behavior induced by substance P injected i. t. On the other hand, we found that i. t. treatment with 50 μg of Rb1, Rb2, Rd, or Rf effectively attenuated the nociceptive behavior induced by i. t. injected substance P. However, the i. t. treatment with the same doses of Rc, Re, Rg1 or Rg3 was not effective for antagonizing i. t. injected substance P-induced nociceptive behavior. Our results show that ginsenosides Rb2, Rc, Rd, or Re injected supraspinally exert a antinociceptive effect in the substance P-induced pain model. Furthermore, Rb1, Rb2, Rd, or Rf treated spinally produce antinociception in the substance P-induced pain model.

Abbreviations

i.c.v.:intracerebroventricular

i.t.:intrathecal

S.E.M.:Standard error of the means

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Professor Hong-Won Suh, Ph. D.

Department of Pharmacology

College of Medicine

Hallym University

1 Okchun-dong

Chunchon

Kangwon Do 200-702

South Korea

Phone: +82-33-248-2614

Fax: +82-33-248-2612

Email: hwsuh@hallym.ac.kr