Abstract
We have examined the effects of several ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1 and Rg3) adminstered intracerebroventricularly (i. c. v.) or intrathecally (i. t.) on the nociceptive behavior induced by substance P (0.7 μg) injected i. t. Among the several ginsenosides studied, Rb2, Rc, Rd, and Re, but not Rb1, Rf, Rg1 and Rg3, treated i. c. v. (50 μg) attenuated the nociceptive behavior induced by substance P injected i. t. On the other hand, we found that i. t. treatment with 50 μg of Rb1, Rb2, Rd, or Rf effectively attenuated the nociceptive behavior induced by i. t. injected substance P. However, the i. t. treatment with the same doses of Rc, Re, Rg1 or Rg3 was not effective for antagonizing i. t. injected substance P-induced nociceptive behavior. Our results show that ginsenosides Rb2, Rc, Rd, or Re injected supraspinally exert a antinociceptive effect in the substance P-induced pain model. Furthermore, Rb1, Rb2, Rd, or Rf treated spinally produce antinociception in the substance P-induced pain model.
Abbreviations
i.c.v.:intracerebroventricular
i.t.:intrathecal
S.E.M.:Standard error of the means
Key Words
Ginsenosides -
Panax ginseng C.A. Meyer - Araliaceae - antinociception - supraspinal - spinally - substance P pain model - mouse
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Professor Hong-Won Suh, Ph. D.
Department of Pharmacology
College of Medicine
Hallym University
1 Okchun-dong
Chunchon
Kangwon Do 200-702
South Korea
Telefon: +82-33-248-2614
Fax: +82-33-248-2612
eMail: hwsuh@hallym.ac.kr
