Planta Med 2003; 69(11): 1031-1035
DOI: 10.1055/s-2003-45151
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Diterpenoids from Isodon enanderianus

Wei Xiang1 , Zhi Na1 , Sheng-Hong Li1 , Ma-Lin Li2 , Rong-Tao Li1 , Qin-E Tian2 , Han-Dong Sun1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Academia Sinica, Kunming, P. R. China
  • 2Yunnan Pharmacological Laboratory of Natural Products, Kunming Medical College, Kunming, P. R. China
Weitere Informationen

Publikationsverlauf

Received: April 8, 2003

Accepted: August 2, 2003

Publikationsdatum:
09. Januar 2004 (online)

Abstract

Five new ent-kaurane diterpenoids, enanderianins K-O (1 - 5), and one new ent-abietane diterpenoid, enanderianin P (6), together with five known ent-kaurane diterpenoids, rabdocoetsin A (7), rabdocoetsin B (8), rabdocoetsin D (9), megathyrin A (10), megathyrin B (11) were isolated from the aerial parts of Isodon enanderianus. Their structures were determined by spectral means. Some diterpenoids were tested for their cytotoxicity against the human tumor K562 cells. Compounds 1, 2, 6, 8, 9 showed significant inhibitory activities against K562 cells with IC50 values ranging from 0.13 to 0.87 μg/mL.

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Prof. Dr. Han-Dong Sun

State Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

Chinese Academy of Sciences

Heilongtan

Kunming 650204

People's Republic of China

Fax: +86-871-5216343

eMail: hdsun@mail.kib.ac.cn