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DOI: 10.1055/s-2003-45154
Cytotoxic Coumarins from Mammea harmandii
We are grateful to the Thailand Research Fund for the award of a Senior Research Scholar to VR. We thank the Development and Promotion of Science and Technology Talent Project (DPST) for providing a scholarship to PL. Financial support from The National Research Council of Thailand (NRCT) and Postgraduate Education and Research Program in Chemistry (PERCH) is also gratefully acknowledgedPublication History
Received: April 29, 2003
Accepted: August 24, 2003
Publication Date:
09 January 2004 (online)
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Abstract
Two new naturally occurring coumarins, isomesuol (1) and mammearin A (2), together with nine known Mammea coumarins 3 - 11 were isolated from the EtOAc extract of the leaves and twigs of Mammea harmandii. Coumarins 1, 3 and 4 showed cytotoxicity against a panel of mammalian cancer cell lines. Their structures were determined by spectroscopic methods. The assignments of 13C-NMR signals of isomesuol (1), which was isolated for the first time as a natural product, have been revised.
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Prof. Vichai Reutrakul
Dr. Patoomratana Tuchinda
Department of Chemistry
Faculty of Science
Mahidol University
Bangkok 10400
Thailand
Phone: +66-2-2015152
Fax: +66-2-6445126
Email: scvrt@mahidol.ac.th
Email: scptc@mahidol.ac.th