Planta Med 2003; 69(11): 1048-1051
DOI: 10.1055/s-2003-45154
Letter
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Coumarins from Mammea harmandii

Vichai Reutrakul1 , Pornsiri Leewanich1 , Patoomratana Tuchinda1 , Manat Pohmakotr1 , Thaworn Jaipetch2 , Samaisukh Sophasan3 , Thawatchai Santisuk4
  • 1Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 2Section of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • 3Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 4The Forest Herbarium, Royal Forestry Department, Bangkok, Thailand
We are grateful to the Thailand Research Fund for the award of a Senior Research Scholar to VR. We thank the Development and Promotion of Science and Technology Talent Project (DPST) for providing a scholarship to PL. Financial support from The National Research Council of Thailand (NRCT) and Postgraduate Education and Research Program in Chemistry (PERCH) is also gratefully acknowledged
Further Information

Publication History

Received: April 29, 2003

Accepted: August 24, 2003

Publication Date:
09 January 2004 (online)

Abstract

Two new naturally occurring coumarins, isomesuol (1) and mammearin A (2), together with nine known Mammea coumarins 3 - 11 were isolated from the EtOAc extract of the leaves and twigs of Mammea harmandii. Coumarins 1, 3 and 4 showed cytotoxicity against a panel of mammalian cancer cell lines. Their structures were determined by spectroscopic methods. The assignments of 13C-NMR signals of isomesuol (1), which was isolated for the first time as a natural product, have been revised.

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Prof. Vichai Reutrakul
Dr. Patoomratana Tuchinda

Department of Chemistry

Faculty of Science

Mahidol University

Bangkok 10400

Thailand

Phone: +66-2-2015152

Fax: +66-2-6445126

Email: scvrt@mahidol.ac.th

Email: scptc@mahidol.ac.th