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Planta Med 2003; 69(11): 1054-1056
DOI: 10.1055/s-2003-45156
Letter
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Alkaloids from the Flowers of Senna spectabilis

Lawan Sriphong1 , Uthai Sotanaphun1 , Siripan Limsirichaikul1 , Penpan Wetwitayaklung1 , Chaiyo Chaichantipyuth2 , Sunibhond Pummangura2
  • 1Faculty of Pharmacy, Silpakorn University, Nakorn Prathom, Thailand
  • 2Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
This work was financially supported by Graduated School, Chulalongkorn University, and the Research Institution of Silpakorn University
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Publikationsverlauf

Received: May 7, 2003

Accepted: August 2, 2003

Publikationsdatum:
09. Januar 2004 (online)

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Abstract

Three new alkaloids, 3(R)-benzoyloxy-2(R)-methyl-6(R)-(11′-oxododecyl)-piperidine (3), 5-hydroxy-2-methyl-6-(11′-oxododecyl)-pyridine (4) and 5-hydroxy-2-methyl-6-(11′-oxododecyl)-pyridine N-oxide (5), together with a known alkaloid, (-)-cassine (1), were isolated from the flowers of Senna spectabilis. A derivative, N,O-diacetylcassine (2), was semisynthesized. Their structures and stereochemistry were established on the basis of spectroscopic analysis. Cytotoxic activity and brine shrimp lethality of these compounds were evaluated. Compounds 2, 3 and 5 exhibited cytoxicity against KB cell lines with IC50 values of 5.2, 3.7 and 2.0 μg/mL, respectively.

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Associate Professor Lawan Sriphong

Department of Pharmaceutical Chemistry

Faculty of Pharmacy

Silpakorn University

Nakorn-Pathom 73000

Thailand

Telefon: +66-34-255800

Fax: +66-34-255801

eMail: lawan@email.pharm.su.ac.th