Die Frühgeborenenretinopathie

C. Jandeck; U. Kellner; M. H. Foerster

doi:10.1055/s-2004-812886

Klinische Monatsblätter für Augenheilkunde, Table of Contents

Klin Monbl Augenheilkd 2004; 221(3): 147-159
DOI: 10.1055/s-2004-812886

Übersicht

Die Frühgeborenenretinopathie

Retinopathy of PrematurityC. Jandeck¹ , U. Kellner¹ , M. H. Foerster¹

¹Universitätsaugenklinik Charité - Universitätsmedizin Berlin, Berlin(Direktor: Prof. Dr. M. H. Foerster)

Abstract

Zusammenfassung

Dieser Übersichtsartikel fasst den aktuellen Stand des Wissens über die Frühgeborenenretinopathie (Retinopathia praematurorum, RPM) zusammen. Kenntnisse über dieses meist bei extrem unreifen Säuglingen auftretende Krankheitsbild sind weiterhin wichtig, da trotz verbesserter neonatologischer Intensivmedizin die RPM auch in Zukunft auftritt, aber durch augenärztliche Screeninguntersuchungen und ggf. durch eine Therapie zum optimalen Zeitpunkt das Erblindungsrisiko deutlich reduziert werden kann. Es werden die historische Entwicklung der RPM kurz dargestellt sowie die neuesten Erkenntnisse der Pathophysiologie beschrieben. Die Ergebnisse der großen multizentrischen Therapiestudien werden zusammengefasst. Die aktuelle deutsche Leitlinie zur Screeninguntersuchung wird erläutert und mit den Empfehlungen anderer Länder verglichen. Die verschiedenen Therapiemöglichkeiten und Behandlungsergebnisse werden diskutiert, derzeit ist die indirekte Laserkoagulation im therapiebedürftigen Stadium die Therapie der Wahl. Die ophthalmologischen Spätveränderungen bei ehemaligen Frühgeborenen werden erwähnt. Am Ende folgt ein Ausblick auf mögliche zukünftige Behandlungsmethoden wie z. B. der Einsatz von antiangiogenen Faktoren.

Abstract

This review summarizes the knowledge and highlights recent advances in clinical research of retinopathy of prematurity (ROP). This disease is still important, because improvements in neonatal intensive care during the last years have increased the survival of the most immature newborns, but did not diminish the ROP frequency. Ophthalmologic screening and, if applicable, laser treatment at the optimal time for advanced ROP prevents blindness in most cases. The history, classification and the modern concepts of ROP pathophysiology are described. The results of various multicenter treatment trials are summarized. The current German screening guidelines are discussed with the guidelines of other nations. The therapeutic treatment strategies and the treatment results are discussed. The ophthalmologic disorders of former preterm infants, as higher rates of amblyopia, strabismus, and refractive error, are mentioned. Possible future therapies, e. g. anti-angiogenic factors are discussed.

Schlüsselwörter

Frühgeborenenretinopathie - RPM - Retinopathia praematurorum - RPM-Screening-Kriterien - Laserkoagulation

Key words

Retinopathy of prematurity - ROP - laser treatment

Full Text

References

Literatur

1 The Committee for the Classification of Retinopathy of Prematurity . An international classification of retinopathy of prematurity. Arch Ophthalmol. 1984; 102 1130-1134
2 Committee on Fetus and Newborn . Vitamin E and the prevention of retinopathy of prematurity. Pediatrics. 1985; 76 315-316
3 The International Committee for the Classification of the Late Stages of Retinopathy of Prematurity . An international classification of retinopathy of prematurity. II. The classification of retinal detachment. Arch Ophthalmol. 1987; 105 906-912
4 Cryotherapy for Retinopathy of Prematurity Cooperative Group . Multicenter trial of cryotherapy for retinopathy of prematurity. Preliminary results. Arch Ophthalmol. 1988; 106 471-479
5 Cryotherapy for Retinopathy of Prematurity Cooperative Group . Multicenter trial of cryotherapy for retinopathy of prematurity. Three-month outcome. Arch Ophthalmol. 1990; 108 195-204
6 Cryotherapy for Retinopathy of Prematurity Cooperative Group . The natural ocular outcome of premature birth and retinopathy. Status at 1 year. Arch Ophthalmol. 1994; 112 903-912
7 Canadian Association of Pediatric Ophthalmologists Ad Hoc Committee on Standards of Screening Examination for Retinopathy of Prematurity . Guidelines for screening examinations for retinopathy of prematurity. Can J Ophthalmol. 2000; 35 251-252; discussion 3 - 4
8 Multicenter Trial of Cryotherapy for Retinopathy of Prematurity: ophthalmological outcomes at 10 years. Arch Ophthalmol. 2001; 119 1110-1118
9 Contrast sensitivity at age 10 years in children who had threshold retinopathy of prematurity. Arch Ophthalmol. 2001; 119 1129-1133
10 Effect of retinal ablative therapy for threshold retinopathy of prematurity: results of Goldmann perimetry at the age of 10 years. Arch Ophthalmol. 2001; 119 1120-1125
11 Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2001; 108 809-811
12 Agostini H T, Hansen L L. Angioproliferative Netzhauterkrankungen bei Ischämie. Ophthalmologe. 2003; 100 371-377
13 Arnold R W, Kesler K, Avila E. Susceptibility to retinopathy of prematurity in Alaskan Natives. J Pediatr Ophthalmol Strabismus. 1994; 31 192-194
14 Sira I Ben, Nissenkorn I, Kremer I. Retinopathy of prematurity. Surv Ophthalmol. 1988; 33 1-16
15 Blodi F C. Symposium: Retrolental fibroplasia (retinopathy of prematurity). Management. Trans Am Acad Ophthalmol Otolaryngol. 1995; 59 35
16 Bolton D P, Cross K W. Further observations on cost of preventing retrolental fibroplasia. Lancet. 1974; 1 (7855) 445-448
17 Bossi E, Koerner F. Retinopathy of prematurity. Intensive Care Med. 1995; 21 241-246
18 Brennan R, Gnanaraj L, Cottrell D G. Retinopathy of prematurity in practice. I: Screening for threshold disease. Eye. 2003; 17 183-188
19 Brooks S E, Johnson M, Wallace D K. et al . Treatment outcome in fellow eyes after laser photocoagulation for retinopathy of prematurity. Am J Ophthalmol. 1999; 127 56-61
20 Bullard S R, Donahue S P, Feman S S. et al . The decreasing incidence and severity of retinopathy of prematurity. J Aapos. 1999; 3 46-52
21 Burgess P, Johnson A. Ocular defects in infants of extremely low birth weight and low gestational age. Br J Ophthalmol. 1991; 75 84-87
22 Caflisch S R, Bucher H U, Santo B. et al . Ophthalmologische Störungen ehemals extrem kleiner Frühgeborener im Alter von 10 Jahren. Monatsschr Kinderheilkd. 1998; 146 230-234
23 Capone A Jr, Trese M T. Lens-sparing vitreous surgery for tractional stage 4A retinopathy of prematurity retinal detachments. Ophthalmology. 2001; 108 2068-2070
24 Carrasquillo K G, Ricker J A, Rigas I K. et al . Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres. Invest Ophthalmol Vis Sci. 2003; 44 290-299
25 Cats B P, Tan K E. Prematures with and without regressed retinopathy of prematurity: comparison of long-term (6 - 10 years) ophthalmological morbidity. J Pediatr Ophthalmol Strabismus. 1989; 26 271-275
26 Charles S. Vitreoretinal surgery for retinopathy of prematurity. Birth Defects Orig Artic Ser. 1988; 24 287-293
27 Clark D I, Laws F, Wood I CJ. et al . Axial growth of the eye and refractive error following retinopathy of prematurity (ROP) - a longitudinal study. Invest Ophthalmol Vis Sci. 1996; 37 370
28 Clemens S, Eckardt C, Gerding H. et al . Leitlinie zur augenärztlichen Screening-Untersuchung von Frühgeborenen. Ophthalmologe. 1999; 96 257-263
29 Cunningham S, Fleck B W, Elton R A. et al . Transcutaneous oxygen levels in retinopathy of prematurity. Lancet. 1995; 346 (8988) 1464-1465
30 Dobson V, Quinn G E, Summers C G. et al . Effect of acute-phase retinopathy of prematurity on grating acuity development in the very low birth weight infant. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Invest Ophthalmol Vis Sci. 1994; 35 4236-4244
31 Dogru M, Shirabe H, Nakamura M. et al . Development of grating acuity in infants with Retinopathy of Prematurity. Acta Ophthalmol Scand. 1999; 77 72-75
32 Fielder A R, Levene M I. Screening for retinopathy of prematurity. Arch Dis Child. 1992; 67 860-867
33 Fielder A R, Shaw D E, Robinson J. et al . Natural history of retinopathy of prematurity: a prospective study. Eye. 1992; 6 233-242
34 Fledelius H C. Prematurity and the eye. Acta Ophthalmol. 1976; 54: Suppl. 128
35 Fledelius H C. Retinopathy of prematurity in Denmark. Epidemiological considerations and screening limits. Eur J Ophthalmol. 1996; 6 183-186
36 Fledelius H C. Pre-term delivery and subsequent ocular development. A 7 - 10 year follow-up of children screened 1982 - 84 for ROP. 3) Refraction. Myopia of prematurity. Acta Ophthalmol Scand. 1996; 74 297-300
37 Fledelius H C. Pre-term delivery and subsequent ocular development. A 7 - 10 year follow-up of children screened 1982 - 84 for ROP. 4) Oculometric - and other metric considerations. Acta Ophthalmol Scand. 1996; 74 301-305
38 Fledelius H C. Pre-term delivery and subsequent ocular development. A 7 - 10 year follow-up of children screened 1982 - 84 for ROP. 1) Visual function, slit-lamp findings, and fundus appearance. Acta Ophthalmol Scand. 1996; 74 288-293
39 Fledelius H C, Dahl H. Retinopathy of prematurity, a decrease in frequency and severity. Trends over 16 years in a Danish county. Acta Ophthalmol Scand. 2000; 78 359-361
40 Flynn J T, Bancalari E, Bachynski B N. et al . Retinopathy of prematurity. Diagnosis, severity, and natural history. Ophthalmology. 1987; 94 620-629
41 Flynn J T. The premature retina: a model for the in vivo study of molecular genetics?. Eye. 1992; 6 161-165
42 Foroozan R, Connolly B P, Tasman W S. Outcomes after laser therapy for threshold retinopathy of prematurity. Ophthalmology. 2001; 108 1644-1646
43 Gallo J E, Lennerstrand G. A population-based study of ocular abnormalities in premature children aged 5 to 10 years. Am J Ophthalmol. 1991; 111 539-547
44 Gaynon M W, Stevenson D K, Sunshine P. et al . Supplemental oxygen may decrease progression of prethreshold disease to threshold retinopathy of prematurity. J Perinatol. 1997; 17 434-438
45 Gibson D L, Sheps S B, Uh S H. et al . Retinopathy of prematurity-induced blindness: birth weight-specific survival and the new epidemic. Pediatrics. 1990; 86 405-412
46 Gilbert C, Rahi J, Eckstein M. et al . Retinopathy of prematurity in middle-income countries. Lancet. 1997; 350 (9070) 12-14
47 Goggin M, O’Keefe M. Diode laser for retinopathy of prematurity - early outcome. Br J Ophthalmol. 1993; 77 559-562
48 Gordon R A, Donzis P B. Myopia associated with retinopathy of prematurity. Ophthalmology. 1986; 93 1593-1598
49 Greven C, Tasman W. Scleral buckling in stages 4B and 5 retinopathy of prematurity. Ophthalmology. 1990; 97 817-820
50 Hartnett M E. Features associated with surgical outcome in patients with stages 4 and 5 retinopathy of prematurity. Retina. 2003; 23 322-329
51 Hatfield E M. Blindness in infants and young children. Sight Sav Rev. 1972; 42 69-89
52 Hellstrom A, Perruzzi C, Ju M. et al . Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci USA. 2001; 98 5804-5808
53 Hindle N W. Cryotherapy for retinopathy of prematurity: timing of intervention. Br J Ophthalmol. 1986; 70 269-276
54 Hiraoka M, Berinstein D M, Trese M T. et al . Insertion and deletion mutations in the dinucleotide repeat region of the Norrie disease gene in patients with advanced retinopathy of prematurity. J Hum Genet. 2001; 46 178-181
55 Hirose T, Schepens C L. Open sky vitrectomy in stage 5 ROP-anatomical and visual results. Presented at the annual meeting of the American Academy of Ophthalmology. New Orleans 1989
56 Hittner H M, Rhodes L M, McPherson A R. Anterior segment abnormalities in cicatricial retinopathy of prematurity. Ophthalmology. 1979; 86 803-816
57 Holmstrom G, el A zazi M, Jacobson L. et al . A population based, prospective study of the development of ROP in prematurely born children in the Stockholm area of Sweden. Br J Ophthalmol. 1993; 77 417-423
58 Holmstrom G, el A zazi M, Kugelberg U. Ophthalmological follow up of preterm infants: a population based, prospective study of visual acuity and strabismus. Br J Ophthalmol. 1999; 83 143-150
59 Horbar J D, McAuliffe T L, Adler S M. et al . Variability in 28-day outcomes for very low birth weight infants: an analysis of 11 neonatal intensive care units. Pediatrics. 1988; 82 554-559
60 Hughes S, Yang H, Chan-Ling T. Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci. 2000; 41 1217-1228
61 Isenberg S J. Macular development in the premature infant. Am J Ophthalmol. 1986; 101 74-80
62 Jandeck C, Kellner U, Helbig H. et al . Natural course of retinal development in preterm infants without threshold retinopathy. Ger J Ophthalmol. 1995; 4 131-136
63 Jandeck C. Refraktionsfehler bei Frühgeborenen mit und ohne Koagulationsbehandlung. Orthoptik-Pleoptik. 1999; 23 25-32
64 Jandeck C, Kellner U, Foerster M H. Späte retinale Komplikationen bei Frühgeborenen mit regressiven Veränderungen. Klin Monatsbl Augenheilkd. 2004; 221 96-100
65 Keith C G. Visual outcome and effect of treatment in stage III developing retrolental fibroplasia. Br J Ophthalmol. 1982; 66 446-449
66 Kellner U, Jandeck C, Helbig H. et al . Überprüfung publizierter Empfehlungen für Screening-Untersuchungen bei Retinopathia praematurorum. Ophthalmologe. 1995; 92 681-684
67 Kinsey V E. Retrolental fibroplasia; cooperative study of retrolental fibroplasia and the use of oxygen. Ama Arch Opthalmol. 1956; 56 481-543
68 Kinsey V E, Arnold H J, Kalina R E. et al . PaO2 levels and retrolental fibroplasia: a report of the cooperative study. Pediatrics. 1977; 60 655-668
69 Krumpaszky H G, Klauss V. [Cause of blindness in Bavaria. Evaluation of a representative sample from blindness compensation records of Upper Bavaria]. Klin Monatsbl Augenheilkd. 1992; 200 142-146
70 Krzystolik M G, Afshari M A, Adamis A P. et al . Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol. 2002; 120 338-346
71 Kumar H, Nainiwal S, Singha U. et al . Stress induced by screening for retinopathy of prematurity. J Pediatr Ophthalmol Strabismus. 2002; 39 349-350
72 Kushner B J, Essner D, Cohen I J. et al . Retrolental fibroplasia. II. Pathologic correlation. Arch Ophthalmol. 1977; 95 29-38
73 Lanman J T, Guy L P, Dancis J. Retrolental fibroplasia and oxygen therapy. J Am Med Assoc. 1954; 155 223-226
74 Larsson E, Carle-Petrelius B, Cernerud G. et al . Incidence of ROP in two consecutive Swedish population based studies. Br J Ophthalmol. 2002; 86 1122-1126
75 Laws D E, Haslett R, Ashby D. et al . Axial length biometry in infants with retinopathy of prematurity. Eye. 1994; 8 (Pt 4) 427-430
76 Laws F, Laws D, Clark D. Cryotherapy and laser treatment for acute retinopathy of prematurity: refractive outcomes, a longitudinal study. Br J Ophthalmol. 1997; 81 12-15
77 Lemons J A, Bauer C R, Oh W. et al . Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network. Pediatrics. 2001; 107 E1
78 Machemer R. Late traction detachment in retinopathy of prematurity or ROP-like cases. Graefes Arch Clin Exp Ophthalmol. 1993; 231 389-394
79 McDonald A D. Cerebral palsy in children of very low birth weight. Arch Dis Child. 1963; 38 579-588
80 McNamara J A, Tasman W, Brown G C. et al . Laser photocoagulation for stage 3 + retinopathy of prematurity. Ophthalmology. 1991; 98 576-580
81 Nagata M, Takishima R. [One side of the coin of functions of public health nursing with the establishment of home care helpers]. Kango. 1968; 20 130-134
82 Ng E Y, Connolly B P, McNamara J A. et al . A comparison of laser photocoagulation with cryotherapy for threshold retinopathy of prematurity at 10 years: part 1. Visual function and structural outcome. Ophthalmology. 2002; 109 928-934; discussion 35
83 NIH News Release. Oxygen restriction can be eased for premature infants with blinding eye disease Press release 2000
84 Nissenkorn I, Yassur Y, Mashkowski D. et al . Myopia in premature babies with and without retinopathy of prematurity. Br J Ophthalmol. 1983; 67 170-173
85 Nissenkorn I, Kremer I, Gilad E. et al . ‘Rush’ type retinopathy of prematurity: report of three cases. Br J Ophthalmol. 1987; 71 559-562
86 Onofrey C B, Feuer W J, Flynn J T. The outcome of retinopathy of prematurity: screening for retinopathy of prematurity using an outcome predictive program. Ophthalmology. 2001; 108 27-34; discussion 5
87 Page J M, Schneeweiss S, Whyte H E. et al . Ocular sequelae in premature infants. Pediatrics. 1993; 92 787-790
88 Palmer E A, Flynn J T, Hardy R J. et al . Incidence and early course of retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Ophthalmology. 1991; 98 1628-1640
89 Paysse E A, Lindsey J L, Coats D K. et al . Therapeutic outcomes of cryotherapy versus transpupillary diode laser photocoagulation for threshold retinopathy of prematurity. J Aapos. 1999; 3 234-240
90 Pearce I A, Pennie F C, Gannon L M. et al . Three year visual outcome for treated stage 3 retinopathy of prematurity: cryotherapy versus laser. Br J Ophthalmol. 1998; 82 1254-1259
91 Penn J S, Tolman B L, Lowery L A. Variable oxygen exposure causes preretinal neovascularization in the newborn rat. Invest Ophthalmol Vis Sci. 1993; 34 576-585
92 Pennefather P M, Clarke M P, Strong N P. et al . Ocular outcome in children born before 32 weeks gestation. Eye. 1995; 9 (Pt 6 Supp) 26-30
93 Pennefather P M, Tin W, Strong N P. et al . Refractive errors in children born before 32 weeks gestation. Eye. 1997; 11 (Pt 5) 736-743
94 Phelps D L. Retinopathy of prematurity: an estimate of vision loss in the United States - 1979. Pediatrics. 1981; 67 924-925
95 Pierce E A, Foley E D, Smith L E. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol. 1996; 114 1219-1228
96 Plate K H, Breier G, Weich H A. et al . Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature. 1992; 359 845-848
97 Pohlandt F. Frühgeburt an der Grenze zur Lebensfähigkeit des Kindes. Z Geburtshilfe Neonatol. 1998; 202 261-263
98 Pollard Z F. Lensectomy for secondary angle-closure glaucoma in advanced cicatricial retrolental fibroplasia. Ophthalmology. 1984; 91 395-398
99 Quinn G E, Johnson L, Abbasi S. Onset of retinopathy of prematurity as related to postnatal and postconceptional age. Br J Ophthalmol. 1992; 76 284-288
100 Quinn G E, Dobson V, Repka M X. et al . Development of myopia in infants with birth weights less than 1251 grams. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Ophthalmology. 1992; 99 329-340
101 Quinn G E, Dobson V, Biglan A. et al . Correlation of retinopathy of prematurity in fellow eyes in the cryotherapy for retinopathy of prematurity study. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Arch Ophthalmol. 1995; 113 469-473
102 Raju T N, Langenberg P, Bhutani V. et al . Vitamin E prophylaxis to reduce retinopathy of prematurity: a reappraisal of published trials. J Pediatr. 1997; 131 844-850
103 Rettwitz-Volk W. [Mortality and morbidity of preterm infants - a synopsis of the german neonatal census 2001]. Z Geburtshilfe Neonatol. 2003; 207 143-147
104 Reynolds J D, Hardy R J, Kennedy K A. et al . Lack of efficacy of light reduction in preventing retinopathy of prematurity. Light Reduction in Retinopathy of Prematurity (LIGHT-ROP) Cooperative Group. N Engl J Med. 1998; 338 1572-1576
105 Riise R. Nordic registers of visually impaired children. Scand J Soc Med. 1993; 21 66-68
106 Robinson R, O’Keefe M. Follow-up study on premature infants with and without retinopathy of prematurity. Br J Ophthalmol. 1993; 77 91-94
107 Saunders R A, Donahue M L, Christmann L M. et al . Racial variation in retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Arch Ophthalmol. 1997; 115 604-608
108 Schalij-Delfos N E, Zijlmans B L, Wittebol-Post D. et al . Screening for retinopathy of prematurity: do former guidelines still apply?. J Pediatr Ophthalmol Strabismus. 1996; 33 35-38
109 Schalij-Delfos N E, Cats B P. Retinopathy of prematurity: the continuing threat to vision in preterm infants. Dutch survey from 1986 to 1994. Acta Ophthalmol Scand. 1997; 75 72-75
110 Seiberth V, Linderkamp O, Akkoyun-Vardarli I. et al . Oxygen therapy in acute retinopathy of prematurity stage 3. Invest Ophthalmol Vis Sci. 1998; 39 S820
111 Seiberth V, Linderkamp O. Risk factors in retinopathy of prematurity. a multivariate statistical analysis. Ophthalmologica. 2000; 214 131-135
112 Seiberth V, Woldt C. Weitwinkelfundusdokumentation bei Retinopathia praematurorum. Ophthalmologe. 2001; 98 960-963
113 Snir M, Nissenkorn I, Sherf I. et al . Visual acuity, strabismus, and amblyopia in premature babies with and without retinopathy of prematurity. Ann Ophthalmol. 1988; 20 256-258
114 STOP-ROP. Supplemental Therapeutic Oxygen for Prethreshold Retinopathy Of Prematurity, a randomized, controlled trial. I: primary outcomes. Pediatrics. 2000; 105 295-310
115 Steinkuller P G, Du L, Gilbert C. et al . Childhood blindness. J Aapos. 1999; 3 26-32
116 Tasman W. Retinal detachment in retrolental fibroplasia (RLF). Bibl Ophthalmol. 1969; 79 371-376
117 Tasman W. Late complications of retrolental fibroplasia. Ophthalmology. 1979; 86 1724-1740
118 Terry T L. Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each cristalline lens I. Preliminary report. Am J Ophthalmol. 1942; 25 203-204
119 The Royal College of Ophthalmologists and the British Association of Perinatal Medicine . Retinopathy of prematurity: guidelines for screening and treatment. The report of a Joint Working Party of The Royal College of Ophthalmologists and the British Association of Perinatal Medicine. Early Hum Dev. 1996; 46 239-258
120 Trese M T, Droste P J. Long-term postoperative results of a consecutive series of stages 4 and 5 retinopathy of prematurity. Ophthalmology. 1998; 105 992-997
121 White J E, Repka M X. Randomized comparison of diode laser photocoagulation versus cryotherapy for threshold retinopathy of prematurity: 3-year outcome. J Pediatr Ophthalmol Strabismus. 1997; 34 83-87
122 Yamashita Y. Studies on retinopathy of prematurity. III. Cryocautery for retinopathy of prematurity. Rinsho Ganka. 1972; 26 385-393
123 Yen K G, Hess D, Burke B. et al . Telephotoscreening to detect retinopathy of prematurity: preliminary study of the optimum time to employ digital fundus camera imaging to detect ROP. J Aapos. 2002; 6 64-70
124 Zilis J D, deJuan E, Machemer R. Advanced retinopathy of prematurity. The anatomic and visual results of vitreous surgery. Ophthalmology. 1990; 97 821-826

Dr. Claudia Jandeck

Universitätsaugenklinik, Charité - Universitätsmedizin Berlin

Campus Benjamin Franklin

Hindenburgdamm 30

12200 Berlin

Phone: +49-30-84 45 23 31

Fax: +49-30-84 45 44 50

Email: claudia.jandeck@charite.de