This article reviews a selection of 50 papers on inflammatory bowel disease published between April 2002 and August 2003. The new information and progress summarized here includes: the role of bacteria, their interaction with CARD15/NOD2 gene products and the modulating effects of probiotics; new imaging techniques, such as wireless capsule endoscopy and chromoendoscopy for detecting dysplasia, and fecal markers. It has not been possible to review every aspect of treatment, and the focus here is on factors capable of predicting the efficacy and tolerance of infliximab and new treatments, including natalizumab, thalidomide, cyclophosphamide and 6-thioguanine.
References
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1
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Crohn’s disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.
Gastroenterology.
2003;
124
140-146
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2
Inohara N, Ogura Y, Fontalba A. et al .
Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn’s disease.
J Biol Chem.
2003;
278
5509-5512
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3
Lala S, Ogura Y, Osborne C. et al .
Crohn’s disease and the NOD2 gene: a role for Paneth cells.
Gastroenterology.
2003;
125
47-57
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4
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Crohn’s disease: a defensin deficiency syndrome?.
Eur J Gastroenterol Hepatol.
2003;
15
627-634
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5
Seksik P, Rigottier-Gois L, Gramet G. et al .
Alterations of the dominant faecal bacterial groups in patients with Crohn’s disease of the colon.
Gut.
2003;
52
237-242
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6
Borruel N, Casellas F, Antolin M. et al .
Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa.
Am J Gastroenterol.
2003;
98
865-870
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7
Gionchetti P, Rizzello F, Helwig U. et al .
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial.
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2003;
124
1202-1209
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8
Prantera C, Scribano M L, Falasco G. et al .
Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn’s disease: a randomised controlled trial with Lactobacillus GG.
Gut.
2002;
51
405-409
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9
Borody T J, Warren E F, Leis S. et al .
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2003;
37
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10
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2002;
51
803-807
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11
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2002;
34
568-572
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13
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2003;
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14
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15
Brooker J C, Beckett C G, Saunders B P, Benson M J.
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2003;
35
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16
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Capsule endoscopy in patients with suspected Crohn’s disease and negative endoscopy.
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2003;
35
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17
Eliakim R, Fischer D, Suissa A. et al .
Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s disease.
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2003;
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363-367
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18
Messmann H, Endlicher E, Freunek G. et al .
Fluorescence endoscopy for the detection of low and high grade dysplasia in ulcerative colitis using systemic or local 5-aminolaevulinic acid sensitisation.
Gut.
2003;
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1003-1007
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19
Kiesslich R, Fritsch J, Holtmann M. et al .
Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.
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2003;
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20
Chen R, Rabinovitch P S, Crispin D A. et al .
DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-free.
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2003;
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21
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770-778
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22
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8
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23
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2003;
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889-893
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24
Laghi A, Borrelli O, Paolantonio P. et al .
Contrast enhanced magnetic resonance imaging of the terminal ileum in children with Crohn’s disease.
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25
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Noninvasive assessment of Crohn’s disease activity: a comparison of 18F-fluorodeoxyglucose positron emission tomography, hydromagnetic resonance imaging, and granulocyte scintigraphy with labeled antibodies.
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26
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27
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2002;
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28
Kane S V, Sandborn W J, Rufo P A. et al .
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29
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2003;
124
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30
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2002;
123
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31
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2002;
51
654-658
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32
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33
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34
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35
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36
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37
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38
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39
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2003;
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40
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41
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44
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46
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Natalizumab for active Crohn’s disease.
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47
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48
Stallmach A, Wittig B M, Moser C. et al .
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2003;
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377-382
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49
Bonaz B, Boitard J, Marteau P. et al .
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Aliment Pharmacol Ther.
2003;
18
401-408
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50
Dubinsky M C, Vasiliauskas E A, Singh H. et al .
6-thioguanine can cause serious liver injury in inflammatory bowel disease patients.
Gastroenterology.
2003;
125
298-303
P. Marteau,M. D., Ph. D.
Gastroenterology Department · Hôpital Européen Georges Pompidou
20, rue Leblanc 75908 Paris Cedex 15 · France
Fax: +33-1-56 09 35 54
Email: philippe.marteau@hop.egp.ap-hop-paris.fr
