Horm Metab Res 2004; 36(3): 194-196
DOI: 10.1055/s-2004-814346
Short Communication
© Georg Thieme Verlag Stuttgart · New York

Increased Plasma Adiponectin in Losartan-treated Type 1 Diabetic Patients. A Mediator of Improved Insulin Sensitivity?

S.  Nielsen1 , A.  S.  Lihn1 , T.  Østergaard1, 2 , C.  E.  Mogensen1 , O.  Schmitz1, 2
  • 1Medical Departments of Endocrinology & Diabetes, Aarhus University Hospitals
  • 2Department of Clinical Pharmacology, University of Aarhus, Denmark
Weitere Informationen

Publikationsverlauf

Received 21 August 2003

Accepted after revision 24 November 2003

Publikationsdatum:
01. April 2004 (online)

Introduction

Adiponectin is a secretory protein derived from adipose tissue with potential insulin sensitizing, anti-inflammatory, and anti-atherogenic properties [1]. Reduced plasma adiponectin concentrations are found in obesity, type 2 diabetes, and coronary artery disease; low plasma levels predict the development of type 2 diabetes in Pima Indians [1]. Conversely, plasma adiponectin increases after weight loss. However, modification of insulin sensitivity without changes in body fat mass, such as chronic physical exercise training [2] and short-term (experimental) changes in plasma free fatty acids (FFA) [3], fail to alter circulating adiponectin concentrations. On the other hand, treatment with insulin-sensitizing thiazolidinediones increases plasma adiponectin in humans [4]. It has therefore been speculated that drugs targeted at increasing adiponectin production may also improve insulin sensitivity and potentially prevent development of type 2 diabetes and atherosclerosis. Treatment of insulin-resistant, essential hypertensive patients with angiotensin II receptor blockers has been shown to be associated with improved sensitivity to insulin mediated glucose metabolism [5] [6] and increased plasma adiponectin concentrations [6]. Recently, we reported improved basal and insulin-mediated glucose metabolism after six weeks of treatment with losartan 50 mg o. d. in a study of normotensive, normoalbuminuric type 1 diabetic men [7]. Here, we have examined whether the effects of losartan on glucose metabolism were associated with changes in plasma adiponectin.

References

  • 1 Diez J J, Iglesias P. .  Eur J Endocrinol. 2003;  148 293-300
  • 2 Hulver M W, Zheng D, Tanner C J, Houmard J A, Kraus W E, Slentz C A, Sinha M K, Pories W J, MacDonald K G, Dohm G L. .  Am J Physiol. 2002;  283 E861-E865
  • 3 Staiger H, Tschritter O, Kausch C, Lammers R, Stumvoll M, Haring H U. .  Horm Metab Res. 2002;  34 601-603
  • 4 Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, Kuriyama H, Hotta K, Nakamura T, Shimomura I, Matsuzawa Y. .  Diabetes. 2001;  50 2094-2099
  • 5 Paolisso G, Tagliamonte M R, Gambardella A, Manzella D, Gualdiero P, Varricchio G, Verza M, Varricchio M. .  J Hum Hypertens. 1997;  11 307-312
  • 6 Furuhashi M, Ura N, Higashiura K, Murakami H, Tanaka M, Moniwa N, Yoshida D, Shimamoto K. .  Hypertension. 2003;  42 76-81
  • 7 Nielsen S, Hove K Y, Dollerup J, Poulsen P L, Christiansen J S, Schmitz O, Mogensen C E. .  Diabetes Obes Metab. 2001;  3 463-471
  • 8 Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama N, Kondo H, Takahashi M, Arita Y, Komuro R, Ouchi N, Kihara S, Tochino Y, Okutomi K, Horie M, Takeda S, Aoyama T, Funahashi T, Matsuzawa Y. .  Nat Med. 2002;  8 731-737
  • 9 Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno N H, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. .  Nature. 2003;  423 762-769
  • 10 van Harmelen V, Skurk T, Rohrig K, Hauner H. .  Horm Metab Res. 2003;  35 466-470
  • 11 Imagawa A, Funahashi T, Nakamura T, Moriwaki M, Tanaka S, Nishizawa H, Sayama K, Uno S, Iwahashi H, Yamagata K, Miyagawa J, Matsuzawa Y. .  Diabetes Care. 2002;  25 1665-1666
  • 12 Perseghin G, Lattuada G, Danna M, Sereni L P, Maffi P, de Cobelli F, Battezzati A, Secchi A, Del M aschio, Luzi L. .  Am J Physiol. 2003;  (in press)

S. Nielsen

Medical Department M (Endocrinology and Diabetes)

Aarhus Kommunehospital · 8000 Aarhus C · Denmark

Telefon: +45(89)492015

Fax: +45(89)492010

eMail: Nielsen.Soren@dadlnet.dk