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DOI: 10.1055/s-2004-815454
© Georg Thieme Verlag Stuttgart · New York
Rearranged Jatrophane-Type Diterpenes from Euphorbia Species. Evaluation of their Effects on the Reversal of Multidrug Resistance
This work was supported by FCT (POCTI, Quadro Comunitário de Apoio III)Publication History
Received: June 6, 2003
Accepted: October 3, 2003
Publication Date:
06 February 2004 (online)
![](https://www.thieme-connect.de/media/plantamedica/200401/lookinside/thumbnails/10.1055-s-2004-815454-1.jpg)
Abstract
The rearranged jatrophane-type diterpenes (1 - 3), isolated from the Me2CO extracts of Euphorbia portlandica and Euphorbia segetalis, were examined for their effects on multidrug resistance (MDR) in mouse lymphoma cells. Compounds 2 and 3 revealed to be active with the latter being more active than the positive control verapamil, a known resistance modifier. The new compound 1, named portlandicine, was isolated from Euphorbia portlandica and its structure characterised by high-field NMR spectroscopic methods including 2D NMR techniques: COSY, HMQC, HMBC and NOESY. The known diterpene 2, together with aleuritolic acid (4), oleanolic acid (5), and betulin diacetate (6), were also isolated from the same species.
Key words
Euphorbia segetalis - Euphorbia portlandica - Euphorbiaceae - Diterpenes - Jatrophane - Triterpenes - multidrug resistance
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Prof. Maria José Umbelino Ferreira
Centro de Estudos de Ciências Farmacêuticas
Faculdade de Farmácia da Universidade de Lisboa
Av. das Forças Armadas
1600-083 Lisboa
Portugal
Fax: +351-21-7946470
Email: mjuferreira@ff.ul.pt