Abstract
A new pentacyclic triterpenoid, 3α-(3′′,4′′-dihydroxy-trans-cinnamoyloxy)-D-friedoolean-14-en-28-oic acid (1) has been isolated along with two known compounds, rhamnocitrin (2) and isorhamnetin (3) from the aerial parts of Tamarix hispida Willd. Compound 1 was found to be a potent antioxidant. In addition, compounds 1 - 3 showed significant inhibitory activity against prolylendopeptidase (PEP).
References
- 1 Sokolov L D. Rastitelnye Resursy USSR. USSR; L. Academ. Nauk 1986: 100-05
- 2 Corbett R E, Cumming S D. Linchens and fungi, part X, 14 α-taraxerane. Journal of
Chemical Society Perkin Transactions I 1972: 2827-9
- 3
Razdan T K, Harkar S.
Phytolaccanol and epiacetylaleuritoric acid, two triterpenoids from Phytolacca acinosa
.
Phytochemistry.
1982;
21
2339-42
- 4
Sharma S K, Parmar V S.
Novel constituents of Tamarix species.
Journal of Scientific and Industrial Research.
1998;
57
873-90
- 5
Nawwar M AM, Sherbeiny A EA, Ansari M AE.
Plant constituents of Tamarix aphylla flowers (Tamaricaceae).
Experientia.
1975;
31
1118
- 6
Sissi H IE, Nawwar M AM, Saleh N AM.
Plant constituents of Tamarix nilotica leaves (Tamaricaceae).
Experientia.
1973;
29
1064
- 7
Noor A K, Kamil M, Ilias M.
Constituents of Tamarix dioica Roxb. (Tamariscineae).
Indian J Chem.
1979;
18B
390
- 8
Kimura K I, Kanou F, Yamashita Y, Yoshimoto T.
Prolyl endopeptidase inhibitors derived from Actinomycetes.
Bioscience Biotechnology Biochemistry.
1997;
61
1754-6
- 9
Fan W, Tezuka Y, Komatsu K, Namba T, Kadota S.
Prolyl endopeptidase inhibitors from the underground part of Rhodiola sacra S. H. Fu.
Biological & Pharmaceutical Bull.
1999;
22
157-61
- 10
Toid K, Shinoda M, Miyazaki A.
A novel prolyl endopeptidase inhibitor, JTP-4819, its behavioral and neurochemical
properties for the treatment of Alzheimer’s disease.
Neuroscience.
1998;
9
17-29
- 11
Lee H J, Song K S.
Kynapcin-12, A new p-terphenyl derivative from Polyozellus multiplex, inhibits prolyl endopeptidase.
The Journal of Antibiotics (Tokyo).
2000;
53
714-9
- 12
Lee S K, Zakaria H, Chung H, Luyengi L, Gamez E JC, Mehta R J, Kinghorn D, Pezzuto J M.
Evaluation of the antioxidant potential of natural products.
Combinatorial Chemistry and High Throughput Screening.
1998;
1
35-46
- 13
Soares J R, Dinis T CP, Cunha A P, Almeida L M.
Antioxidant activities of some extracts of Thymus zygis
.
Free Rad Res.
1997;
26
469-78
- 14
Yoshimoto T, Walter R, Tsuru D.
Proline-specific endopeptidase from Flavobacterium
.
Journal of Biological Chemistry.
1980;
255
4786-92
Prof. M. Iqbal Choudhary
HEJ Research Institute of Chemistry
University of Karachi
Karachi-75270
Pakistan
Fax: +9221 9243190, 9243191
Email: hej@cyber.net.pk