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Planta Med 2004; 70(1): 87-89
DOI: 10.1055/s-2004-815466
Letter
© Georg Thieme Verlag Stuttgart · New York

New Halimane Diterpenoids from Croton oblongifolius

Sophon Roengsumran1 , Surachai Pornpakakul1 , Nongnuj Muangsin1 , Polkit Sangvanich1 , Thumnoon Nhujak1 , Pravit Singtothong1 , Narongsak Chaichit2 , Songchan Puthong3 , Amorn Petsom3
  • 1Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
  • 2Department of Physics, Faculty of Science and Technology, Thammasart University, Rangsit, Pathum Thani, Thailand
  • 3Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok, Thailand
The authors express their gratitude to the Rachadapiseksompoj Endowment and Graduate School, Chulalongkorn University for financial support. We also thank the National Research Council of Thailand for partial financial support.
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Publikationsverlauf

Received: June 24, 2003

Accepted: November 8, 2003

Publikationsdatum:
06. Februar 2004 (online)

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Abstract

Three new halimane-type diterpenoids, crotohalimaneic acid (1), crotohalimoneic acid (2) and 12-benzoyloxycrotohalimaneic acid (3), were isolated from the stem bark of Croton oblongifolius Roxb. Their structures were established on the basis of spectroscopic and X-ray analysis. Compounds 1 and 2 showed non-specific strong cytotoxicity against a panel of human tumor cell lines; whereas 3 was inactive.

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Dr. Sophon Roengsumran

Department of Chemistry

Faculty of Science

Chulalongkorn University

Bangkok 10330

Thailand

Fax: +66-2-218-7598

eMail: amorn.p@chula.ac.th