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DOI: 10.1055/s-2004-815483
Anti-Inflammatory Compounds of Plant Origin. Part II. Modulation of Pro-Inflammatory Cytokines, Chemokines and Adhesion Molecules
Part 1: Planta Med 2003;69:973 - 983Michel F. Otuki is a PhD student in Pharmacology and he thanks CNPq for scholarship support. Maria M. Campos holds a post-doctoral fellowship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). The studies from our group were supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (FINEP) and by Programa de Apoio aos Grupos de Excelência (PRONEX), BrazilPublikationsverlauf
Received: August 18, 2003
Accepted: October 18, 2003
Publikationsdatum:
02. März 2004 (online)
Abstract
It has been widely shown that many plant-derived compounds present significant anti-inflammatory effects. For this reason, they represent potential molecules for the development of new drugs, especially designed for the treatment and/or control of chronic inflammatory states such as rheumatism, asthma, inflammatory bowel diseases, atherosclerosis, etc. This review focuses on the naturally-occurring compounds with anti-inflammatory properties and attempts to correlate their actions with the modulation of cytokines and associated intracellular signalling pathways; it continues the review published in the November, 2003 issue of Planta Medica.
Abbreviations
AP-1:activator protein-1
CCR1:chemokine receptor 1
CINC-1:cytokine-induced neutrophil chemoattractant 1
COX:cyclooxygenase
EGCG:(-)-epigallocatechin gallate
ELAM-1:endothelial-leukocyte adhesion molecule-1
ERK:extracellular signal-regulated kinase
GRO:growth-related oncogene
HUVEC:human umbilical vein endothelial cells
ICAM-1:intercellular adhesion molecule-1
IFN:interferon
IL:interleukin
iNOS:inducible nitric oxide synthase
IRA:the natural interleukin receptor activation
JAK:janus kinase
JNK:c-Jun NH2-terminal kinase
LPS:lipopolysaccharide
MAPK:mitogen-activated protein kinases
MCP:monocyte chemotactic protein
MHC:major histocompatibility complex
MIP:macrophage inflammatory protein
MMP:matrix metalloproteinases
MPO:myeloperoxidase
NF-κBnuclear factor kappa B
NO:nitric oxide
PAF:platelet aggregation factor
PGEE:prostaglandin
PK:protein kinase
PMA/TPA:phorbol myristate acetate
RANTES:regulated upon activation normal T-cell expressed and secreted
TGF-β:transforming growth factor-β
TNFα:tumour necrosis factor
VCAM-1:vascular cell adhesion molecule-1
Key words
Medicinal plants - plant constituents - inflammation - cytokines - chemokines - adhesion molecules
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João B. Calixto
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