Planta Med 2004; 70(2): 171-173
DOI: 10.1055/s-2004-815496
Letter
© Georg Thieme Verlag Stuttgart · New York

Anti-Angiogenic Activity of a Homoisoflavanone from cremastra appendiculata

Joong Sup Shim1 , Jin Hee Kim1 , Jiyong Lee1 , Si Na Kim1 , Ho Jeong Kwon1
  • 1Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Kwangjin-gu, Seoul, Korea
This study was supported by a grant of the Ministry of Health & Welfare, Republic of Korea (HMP-99-D-01-0004) and the Brain Korea 21 project
Further Information

Publication History

Received: July 7, 2003

Accepted: October 18, 2003

Publication Date:
02 March 2004 (online)

Abstract

A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one (1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

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Prof. Ho Jeong Kwon

Department of Bioscience and Biotechnology

Institute of Bioscience

Sejong University

98 Kunja-dong

Kwangjin-gu

Seoul 143-747

Korea

Phone: +82-2-3408-3640

Fax: +82-2-3408-3334

Email: kwonhj@sejong.ac.kr