New Lignans and Cytotoxic Constituents from Wikstroemia lanceolata

Abstract

Two new lignans, (-)-aptosimon (1) and (-)-diasesamin-di-γ-lactone (2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known sesquiterpenoid, 1α,7α,10αH-guaia-4,11-dien-3-one (24) were revised by 2D NMR techniques. Among the isolates, three compounds, (+)-hinokinin (6), 2,6-dimethoxy-p-benzoquinone (17), and 1α,7α,10αH-guaia-4,11-dien-3-one (24) exhibited effective cytotoxicities (ED₅₀ values < 4.0 μg mL^-1) against P-388 and HT-29 tumor cell lines.

Key words

Wikstroemia lanceolata - Thymelaeaceae - stem - root - lignans - aptosimon - diasesamin-di-γ-lactone - sesquiterpenoids - cytotoxicity

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