The Role of Bone Marrow Stem Cells in Liver Regeneration

Markus Grompe

doi:10.1055/s-2004-815560

Seminars in Liver Disease, Table of Contents

Semin Liver Dis 2003; 23(4): 363-372
DOI: 10.1055/s-2004-815560

The Role of Bone Marrow Stem Cells in Liver Regeneration

Markus Grompe

Professor, Department of Molecular and Medical Genetics L103, Oregon Health and Science University, Portland, Oregon

Abstract

ABSTRACT

Hepatic oval cells involved in some forms of liver regeneration express many markers also found on hematopoietic stem cells (HSCs). In addition, multiple independent reports have demonstrated that bone marrow cells can give rise to several hepatic epithelial cell types, including oval cells, hepatocytes, and duct epithelium. These observations have resulted in the hypothesis that bone marrow resident stem cells, specifically HSCs, are an important source for liver epithelial cell replacement, particularly during chronic injury. The function of such stem cells in hepatic injury responses is the topic of this article. Taken together, the published data on the role of bone marrow stem cells in liver damage suggest that they do not play a significant physiological role in the replacement of epithelial cells in any known form of hepatic injury. Fully functional bone marrow-derived hepatocytes exist but are extremely rare and are generated by cell fusion, not stem cell differentiation. Nonetheless, bone marrow-derived cells may play important indirect roles in liver regeneration. First, they may serve as a source for the replacement of endothelial cells. Second, hematopoietic cells, including lymphocytes, neutrophils, macrophages, and platelets, may provide crucial factors required for efficient healing of damaged liver.

KEYWORDS

Liver stem cell - hematopoietic stem cell - stem cell plasticity - bone marrow-derived hepatocyte - liver injury

Full Text

References

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