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Semin Thromb Hemost 2003; 29(6): 619-632
DOI: 10.1055/s-2004-815629
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

New Anticoagulants

Lori-Ann Linkins1,3 , Jeffrey I. Weitz2,3
  • 1Research Fellow, Henderson Research Centre and McMaster University, Hamilton, Ontario, Canada
  • 2Professor, Henderson Research Centre and McMaster University, Hamilton, Ontario, Canada
  • 3Director, Henderson Research Centre and McMaster University, Hamilton, Ontario, Canada
Further Information

Publication History

Publication Date:
13 January 2004 (online)

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ABSTRACT

The limitations of heparin and warfarin have prompted the search for new anticoagulants for the prevention and treatment of venous and arterial thromboembolism. Although many such agents are in development, only a few have reached phase II or higher levels of clinical testing. This article reviews venous and arterial thrombogenesis, discusses the regulation of coagulation, identifies the molecular targets for new anticoagulants currently under development, describes the agents in more advanced stages of clinical testing, and provides clinical perspective on the opportunities for new anticoagulant drugs.

KEYWORDS

Anticoagulants - thromboembolism - heparin - warfarin - thrombin inhibitor - factor Xa inhibitors

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