Exp Clin Endocrinol Diabetes 2004; 112(1): 24-28
DOI: 10.1055/s-2004-815723
Article

J. A. Barth Verlag in Georg Thieme Verlag Stuttgart · New York

Hormonal Profile of Men with Premature Balding

L. Stárka 1 , I. Čermáková 1 , M. Dušková 1 , M. Hill 1 , M. Doležal 2 , V. Poláček 2
  • 1Institute of Endocrinology, Prague, Czech Republic
  • 2Clinics of Aesthetic Surgery, Faculty Hospital, Bulovka, Prague, Czech Republic
Further Information

Publication History

Received: November 25, 2002 First decision: January 29, 2003

Accepted: June 4, 2003

Publication Date:
03 February 2004 (online)

Abstract

Objective

Premature androgenic alopecia has been suggested as a feature of the male equivalent of the syndrome of polycystic ovary. However, the hormonal pattern of men with premature balding has been investigated in only a few studies with inconsistent results.

Material and Methods

We examined 37 men with premature balding (defined as frontoparietal and vertex hair loss before the age of 30 years with alopecia defined as grade 3 vertex or more on the alopecia classification scale of Hamilton with Norwood modification). The plasma concentrations of total testosterone, dihydrotestosterone, epitestosterone, androstenedione, cortisol, 17-OH-progesterone (17OHP), estradiol, LH, FSH, prolactin, SHBG and TSH and free thyroxine were measured.

Results

The frequency of subnormal values in SHBG, FSH, testosterone and epitestosterone (but not in free androgen index) was significant in the balding men. A borderline significant trend was recorded with respect to increased levels in 17OH-P and prolactin.

Conclusions

The hormonal pattern of a substantial number of men with premature balding resembles in some respects the hormonal pattern of women with polycystic ovary syndrome.

References

  • 1 Bílek R, Hampl R, Putz Z, Stárka L. Radioimmunoassay of epitestosterone: methodology, thermodynamic aspects and applications.  J Steroid Biochem. 1987;  28 723-729
  • 2 Bonn D. Is PCOS a risk factor for atherosclerosis?.  Lancet. 2000;  356 1742
  • 3 Carey A H, Chan K L, Short F, White D, Williamson R, Franks S. Evidence for a single gene effect causing polycystic ovaries and male pattern baldness.  Clin Endocrinol. 1993;  38 653-658
  • 4 Choi M H, Yoo Y S, Chung B C. Biochemical roles of testosterone and epitestosterone to 5α-reductase as indicator of male-pattern baldness.  J Invest Dermatol. 2001;  116 57-61
  • 5 Cipriani R, Ruzza G, Foresta C, Veller Fornasa C, Peserico A. Sex hormone-binding globulin and saliva testosterone levels in men with androgenetic alopecia.  Br J Dermatol. 1983;  109 249-252
  • 6 Cooper H E, Spellacy W N, Prem K A, Cohen W D. Hereditary factors in the Stein-Leventhal syndrome.  Am J Obstet Gynecol. 1968;  100 371-387
  • 7 Ferriman D, Purdie A W. The inheritance of polycystic ovarian disease and possible relation to premature balding.  Clin Endocrinol. 1979;  11 291-300
  • 8 Georgala G, Papasotiriou V, Stavropoulos P. Serum testosterone and sex hormone binding globulin levels in women with androgenetic alopecia.  Acta Derm Venerol. 1986;  66 532-534
  • 9 Givens J R. Familial polycystic ovarian disease.  Endocrinol Clin N Amer. 1988;  17 771-783
  • 10 Govind A, Obhrai M S, Clayton R N. Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families.  J Clin Endocrinol Metab. 1999;  84 38-43
  • 11 Hampl R, Putz Z, Stárka L. Radioimmmunological determination of dihydrotestosterone and its value for laboratory diagnostics.  Biochemia Clin Bohemoslov. 1990;  19 157-163
  • 12 Hawk E, Breslow R A, Graubard B I. Male pattern baldness and clinical prostate cancer in the epidemiologic follow-up of the first NHNE Survey.  Cancer Epid Biomarkers Prev. 2000;  5 523-527
  • 13 Hibberts N A, Howell A E, Randall V A. Balding hair follicle dermal papilla cells contain higher levels androgen receptors than those from non-balding scalp.  J Endocrinol. 1998;  156 59-65
  • 14 Legro R S, Finegood D, Dunaif A. A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome.  J Clin Endor Metab. 1998;  83 2694-2698
  • 15 Legro R S. Is there a male phenotype in polycystic ovary syndrome families?.  J Ped Endocr Metab. 2000;  13 (Suppl 5) 1307-1309
  • 16 Lotufo P A, Chae C U, Ajani U A, Hennekens C H, Manson J E. Male pattern baldness and coronary heart disease: the Physicians' Health Study.  Arch Intern Med. 2000;  160 165-171
  • 17 Lunde O, Magnus P, Sandvik L, Hoglo S. Familial clustering in the polycystic ovarian syndrome.  Gynecol Obstetr Invest. 1989;  28 23-30
  • 18 Matilainen V, Koskela P, Keinanen-Kiukaanniemi S. Early androgenetic alopecia as a marker of insulin resistance.  Lancet. 2000;  356 1165-1166
  • 19 Matilainen V A, Makinen P K, Keinanen-Kiukaanniemi S M. Early onset of androgenetic alopecia associated with early severe coronary heart disease: a population-based, case-control study.  J Cardiovasc Risk. 2001;  8 147-151
  • 20 Matilainen V A, Keinanen-Kiukaanniemi S M. Hormone-induced aberrations in electromagnetic adhesion signaling as a developmental factor of androgenetic alopecia.  Med Hypotheses. 2002;  58 261-263
  • 21 Norman R J, Masters S, Hague W. Hyperinsulinemia is common in family members of women with polycystic ovary syndrome.  Fertil Steril. 1996;  66 924-947
  • 22 Norwood O T. Male pattern baldness: classification and incidence.  South Med J. 1975;  68 1359-1365
  • 23 Schmidt J B, Lindmaier A, Spona J. Hormonal parameters in androgenetic hair loss in the male.  Dermatologica. 1991 a;  182 214-217
  • 24 Schmidt J B, Lindmaier A, Trenz A, Schurz Spona B J. Hormone studies in females with androgenic hairloss.  Gynecol Obstet Invest. 1991 b;  31 235-239

Prof. MUDr. RNDr. DrSc. L. Stárka

Institute of Endocrinology
11694 Prague 1
Czech Republic

Národní 8

Phone: + 420224905344

Fax: + 42 02 24 90 53 25

Email: lstarka@endo.cz