Abstract
An excellent method for a one-pot conversion of N-protected α-aminoalkylphosphonous acids into the corresponding monomethyl phosphonates, using thionyl chloride in methanol, has been devised. N-Protected monomethyl α-aminoalkylphosphonates are valuable intermediates in the preparation of phosphapeptides.
Key words
α-aminoalkylphosphonous acids - α-aminoalkylphosphonate monomethyl esters - thionyl chloride - oxidation - selective esterification
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