Solvent-Free Synthesis of 6-Arylbenzimidazo[1,2-c]quinazolines under Microwave­ Irradiation

Hernán Pessoa-Mahana; C. David Pessoa-Mahana; Ricardo Salazar; Jaime A. Valderrama; Edmundo Saez; Ramiro Araya-Maturana

doi:10.1055/s-2004-815924

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Solvent-Free Synthesis of 6-Arylbenzimidazo[1,2- c ]quinazolines under Microwave Irradiation

Hernán Pessoa-Mahana*^a, C. David Pessoa-Mahana^b, Ricardo Salazar^a, Jaime A. Valderrama^c, Edmundo Saez^b, Ramiro Araya-Maturana^a
^a Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 1, Chile
Fax: +56(2)6782868; e-Mail: hpessoa@ciq.uchile.cl;
^b Departamento de Farmacia, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile
^c Departamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile

Abstract

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Abstract

The syntheses of 2-(2-nitrophenyl)-1-benzoyl-1H-benzimidazole derivatives 5-9 and their reduction to the corresponding 2-benzimidazoylbenzamides 10-13 are described. Compounds 10-13 were cleanly and efficiently converted to the corresponding 6-arylbenzimidazo[1,2-c]quinazolines 17-20 by microwave activation using SiO₂-MnO₂ as solid inorganic support.

Key words

benzimidazoles - heterocyclization - microwaves - benzimidazoquinazolines - solvent-free reactions

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References

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Solvent-Free Synthesis of 6-Arylbenzimidazo[1,2- c ]quinazolines under Microwave­ Irradiation

Solvent-Free Synthesis of 6-Arylbenzimidazo[1,2- c ]quinazolines under Microwave Irradiation