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Synthesis 2004(4): 605-609
DOI: 10.1055/s-2004-815948
DOI: 10.1055/s-2004-815948
PAPER
© Georg Thieme Verlag Stuttgart · New York
A New, One Pot Synthesis of Alkylated Methyl Tri- and Tetracarboxylate Derivatives by Nitrolkanes
Further Information
Received
22 December 2003
Publication Date:
03 February 2004 (online)
Publication History
Publication Date:
03 February 2004 (online)
Abstract
The reaction of nitroalkanes with trimethyl trans-aconitate in acetonitrile, in the presence of DBU as base, allows the one pot formation of alkylated methyl tri- and tetralkanoate derivatives via base induced nitrous acid elimination. The title compounds can also be obtained, in one flask, starting with the reaction of methyl nitroacetate with dimethyl maleate, followed by the addition, in the same flask of the nitroalkane.
Key words
nitroalkanes - dimethyl maleate - methyl trialkanoate - methyl tetraalkanoate - triols
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