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Synthesis 2004(3): 341-344
DOI: 10.1055/s-2004-815953
DOI: 10.1055/s-2004-815953
PAPER
© Georg Thieme Verlag Stuttgart · New York
Novel α-Hydroxy-α-(2-hydroxy-1-naphthyl)acetic Acid and its Derivatives. Preparation and Optical Resolution
Further Information
Received
30 October 2003
Publication Date:
03 February 2004 (online)
Publication History
Publication Date:
03 February 2004 (online)
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Abstract
A facile preparation of novel α-hydroxy-α-(2-hydroxy-1-naphthyl)acetic acid by a base-catalyzed condensation of 2-naphthol with glyoxylic acid is described. One of its derivatives, α-methoxy-α-(2-methoxy-1-naphthyl)acetic acid, has successfully been resolved.
Key words
α-hydroxy-α-(2-hydroxy-1-naphthyl)acetic acid - α-methoxy-α-(2-methoxy-1-naphthyl)acetic acid - 2-naphthol - glyoxylic acid - optical resolution
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