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Synthesis 2004(4): 521-524
DOI: 10.1055/s-2004-815954
DOI: 10.1055/s-2004-815954
PAPER
© Georg Thieme Verlag Stuttgart · New York
Novel and Convenient Aldolization of Methyl 3,3,3-Trifluoropyruvate Using Enamines Instead of Ketones
Further Information
Received
11 August 2003
Publication Date:
03 February 2004 (online)
Publication History
Publication Date:
03 February 2004 (online)
Abstract
Piperidine enamines derived from acetone, acetophenone, cyclopentanone and cyclohexanone react easily in minutes with methyl 3,3,3-trifluoropyruvate (1) to afford products of the aldol condensation in high yields at room temperature, which is in contrast to the direct aldolization of 1 with the ketones.
Key words
piperidines - nucleophilic additions - ketones - ene reactions - aldol reactions
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