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Synthesis 2004(4): 506-508  
DOI: 10.1055/s-2004-815961
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A Rapid and Efficient Synthesis of 2-Butyl-5-Chloro-3H-Imidazole-4-Carboxaldehyde

K. Srinivas*, C. K. Snehalatha Nair, S. Ramesh, M. Pardhasaradhi
Specialty Gas Based Chemicals & Processes Division, FCL Lab, Indian Institute of Chemical Technology, Hyderabad 500 007, India
e-Mail: kantevari@yahoo.com;
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Publikationsverlauf

Received 22 December 2003
Publikationsdatum:
09. Februar 2004 (online)

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Abstract

A rapid, efficient, cost effective procedure has been developed for the synthesis of 2-butyl-5-chloro-3H-imidazole-4-carboxaldehyde. Preparation of methyl pentanimidate was accomplished in just 12 hours, followed by a sequence of reactions without isolation and purification of the formed intermediates. The final compound was purified by simple acid-base treatment to get a product with 99.9% HPLC purity.

Key words

imidazole - imidates - Vilsmeier reagents - nitrile - tetrazole

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