Abstract
A simple and facile preparation of chiral and bis-pyrroles is described here. This method involves a modified Paal-Knorr reaction using 1,4-dicarbonyl systems derived from ozonolysis of allylated β-ketoester.
Key words
Paal-Knorr synthesis - chiral and bispyrroles - ozonolysis - allylated β-ketoester
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14 Solvents such as MeOH, CH3 CN, THF, EtOAc, CH2 Cl2 , and toluene were screened with CH3 CN giving the highest yield and cleanest products as determined by LCMS. The reactions were also run at r.t., 50 °C, and 80 °C to determine the optimal temperature. A variety of acids such as aq HCl and aq H2 SO4 were screened in addition to p -TsOH.
