Simple One-Pot Three-Component Synthesis of 2-Oxo-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinolines

Abstract

Isoquinoline reacts smoothly with dialkyl acetylenedicarboxylates in the presence of isocyanates to produce dialkyl 2-oxo-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates in good yields.

Key words

isocyanates - cyclizations - heterocycles - quinolines - isoquinolines - alkynes

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