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DOI: 10.1055/s-2004-817906
Georg Thieme Verlag KG Stuttgart · New York
Acute Haemorrhagic Encephalomyelitis (AHEM): MRI Findings
Publication History
Received: May 6, 2003
Accepted after Revision: January 29, 2004
Publication Date:
04 May 2004 (online)
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Abstract
Acute disseminated encephalomyelitis (ADEM) comprises a group of demyelinating disorders of the CNS, of which a haemorrhagic variant indicates the most severe clinical course (AHEM). It is supposed to be caused by an overshooting immunological response following an infection or a vaccination. Restricted diffusion of protons could be demonstrated using DW-MRI in a case of rapidly progressive disease with additional haemorrhage. Hence, the addition of DWI adds to the diagnostic power of MRI in the setting of post-infectious demyelinating disorders of the CNS.
Key words
ADEM - MRI - AHEM - DWI
References
- 1 Dale R C, de Sousa C, Chong W K, Cox T C, Harding B, Neville B G. Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain. 2000; 123 2407-2422
- 2 Hurst A E. Acute hemorrhagic leukoencephalitis: a previously undefined entity. Med J Aust. 1941; 1 1-6
- 3 Huseby E S, Liggitt D, Brabb T, Schnabel B, Ohlen C, Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med. 2001; 194 669-676
- 4 Khong P L, Ho H K, Cheng P W, Wong V C, Goh W, Chan F L. Childhood acute disseminated encephalomyelitis: the role of brain and spinal cord MRI. Pediatr Radiol. 2002; 32 59-66
- 5 Klein C J, Wijdicks E F, Earnest F T. Full recovery after acute hemorrhagic leukoencephalitis (Hurst's disease). J Neurol. 2000; 247 977-979
- 6 Mader I, Stock K W, Ettlin T, Probst A. Acute disseminated encephalomyelitis: MR and CT features. Am J Neuroradiol. 1996; 17 104-109
- 7 Murthy S N, Faden H S, Cohen M E, Bakshi R. Acute disseminated encephalomyelitis in children. Pediatrics. 2002; 110 21
- 8 Ohta K, Obara K, Sakauchi M, Takane H, Yogo Y. Lesion extension detected by diffusion-weighted magnetic resonance imaging in progressive multifocal leukoencephalopathy. J Neurol. 2001; 248 809-811
- 9 Pfausler B, Engelhardt K, Kampfl A, Spiss H, Taferner E, Schmutzhard E. Post-infectious central and peripheral nervous system diseases complicating mycoplasma pneumoniae infection. Report of three cases and review of the literature. Eur J Neurol. 2002; 9 93-96
- 10 Sugaya N. Influenza-associated encephalopathy in Japan. Semin Pediatr Infect Dis. 2002; 13 79-84
- 11 Tenembaum S, Chamoles N, Fejerman N. Acute disseminated encephalomyelitis: A long-term follow-up study of 84 pediatric patients. Neurology. 2002; 59 1224-1231
- 12 Voudris K A, Skaardoutsou A, Haronitis I, Vagiakou E A, Zeis P M. Brain MRI findings in influenza A-associated acute necrotizing encephalopathy of childhood. Eur J Paediatr Neurol. 2001; 5 199-202
Dr. W. Küker
Department of Neuroradiology · University Hospital Tübingen
Hoppe-Seyler-Straße 3
72076 Tübingen
Germany
Email: wmkueker@med.uni-tuebingen.de