Abstract
Intracranial schwannomas, accounting for 8 to 10 % of all primary brain neoplasms, are relatively frequent intracranial tumors, but a “pure” intrasellar localization is exceptional. We report the case of an intra-suprasellar schwannoma mimicking a non-functioning pituitary macroadenoma both radiographically and clinically. A 73-year-old man presented with an episode of lipothymia followed by episodes of mental confusion. The neurological investigations revealed a bitemporal hemianopia and a hypopituitaric status. The neuroradiological investigations showed an intra-suprasellar mass resembling a pituitary adenoma. The patient underwent surgery performed by means of an endoscopic endonasal transsphenoidal approach, with a subtotal excision of the tumor. The histopathological studies revealed a cellular schwannoma. The review of the literature disclosed another 8 cases of intrasellar schwannomas. The possibility of an intrasellar schwannoma has to be considered in the differential diagnoses of neoplastic and non-neoplastic lesions of the sellar area.
Key words
Transsphenoidal surgery - endoscopic approach - schwannoma - pituitary
References
-
1
Chadduck W M.
Unusual lesions involving the sella turcica.
South Med J.
1973;
66
948-955
-
2
Civit T, Pinelli C, Klein M, Auque J, Baylac F, Hepner H.
Intrasellar schwannoma.
Acta Neurochir (Wien).
1997;
139
160-161
-
3
Goebel H H, Shimokawa K, Schaake T, Kremp A.
Schwannoma of the sellar region.
Acta Neurochir (Wien).
1979;
48
191-197
-
4
Guenot M, Bataille B, Wager M.
Intrasellar neurinoma.
Neurochirurgie.
1994;
40
263-266
-
5
Ishige N, Ito C, Saeki N, Oka N.
Neurinoma with intrasellar extension.
No Shinkei Geka.
1985;
13
79-84
-
6
Kasantikul V, Shuangshoti S, Preechayudh P, Wangsuphachart S.
A combined neurilemmoma and angioma of the parasellar region.
J Neurosurg.
1987;
67
307-311
-
7
Perone T P, Robinson B, Holmes S M.
Intrasellar schwannoma.
Neurosurgery.
1984;
14
71-73
-
8
Wilberger J E.
Primary intrasellar schwannoma: case report.
Surg Neurol.
1989;
32
156-158
-
9
Hardy J.
Comment to the article: Maartens NF, Ellegala DB, Vance ML, Lopes MBS, Laws ER. Intrasellar schwannomas: report of two cases.
Neurosurgery.
2003;
52
1205
-
10
Maartens N F, Ellegala D B, Vance M L, Lopes M BS, Laws E R.
Intrasellar schwannomas: report of two cases.
Neurosurgery.
2003;
52
1200-1206
-
11
Whee S M, Lee J, Kim J H.
Intrasellar schwannoma mimicking pituitary adenoma: a case report.
J Korean Med Sci.
2002;
17
147-150
-
12
Cappabianca P, Alfieri A, Divitiis E de.
Endoscopic endonasal transsphenoidal approach to the sella: towards functional endoscopic pituitary surgery (FEPS).
Minim Invasive Neurosurg.
1998;
41
66-73
-
13
Cappabianca P, Cavallo L M, Colao A, Del Basso De Caro M, Esposito F, Cirillo S, Lombardi G, Divitiis E de.
Endoscopic endonasal transsphenoidal approach: outcome analysis of 100 consecutive procedures.
Minim Invasive Neurosurg.
2002;
45
1-8
-
14
Cappabianca P, Cavallo L M, Esposito F, Valente V, Divitiis E de.
Sellar repair in endoscopic endonasal transsphenoidal surgery: results of 170 cases.
Neurosurgery.
2002;
51
1365-1372
-
15
Carrau R L, Jho H D, Ko Y.
Transnasal-transsphenoidal endoscopic surgery of the pituitary gland.
Laryngoscope.
1996;
106
914-918
-
16 Divitiis E de, Cappabianca P. Endoscopic endonasal transsphenoidal surgery. In: Pickard JD (eds.). Advances and Technical Standards in Neurosurgery. Berlin, Heidelberg: Springer Verlag 2002 Vol. 27: 137-177
-
17
Divitiis E de, Cappabianca P, Cavallo L M.
Endoscopic transsphenoidal approach: adaptability of the procedure to different sellar lesions.
Neurosurgery.
2002;
51
699-707
-
18 Jho H D, Carrau R L, Ko Y. Endoscopic pituitary surgery. In: Wilkins RH, Rengachary SS (eds.). Neurosurgical Operative Atlas. Park Ridge III: American Association of Neurological Surgeons 1996 5: 1-12
-
19
Gray M H, Rosenberg A E, Dickersin G R, Bahn A K.
Glial fibrillary acidic protein and keratin expression by benign and malignant nerve sheath tumors.
Hum Pathol.
1989;
20
1089-1096
-
20
Deruaz J P, Janzer R C, Costa J.
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas.
J Neuropathol Exp Neurol.
1993;
52
114-118
-
21
Scheithauer B W, Casadei G P, Manfrini M, Wood M B.
Cellular schwannoma: a clinicopathological study of 56 cases.
J Neuropathol Exp Neurol.
1993;
52
329
-
22
Seppälä M T, Haltia M J.
Spinal malignant nerve sheath tumor or cellular schwannoma? A striking difference in prognosis.
J Neurosurg.
1993;
79
528-532
-
23 Woodruff J M, Kourea H P, Louis D N, Scheithauer B W. Schwannoma. In: Kleihues P, Cavenee WK (eds.). WHO Classification of Tumors, Pathology and Genetics: Tumors of the Central Nervous System. Lyon: IARC Press 2000: 164-166
-
24
Stefansson K, Wollmann R, Jerkovic M.
S-100 protein in soft-tissue tumors derived from Schwann cells and melanocytes.
Am J Pathol.
1982;
106
261-268
Prof. Paolo Cappabianca
Dipartimento di Scienze Neurologiche · Cattedra di Neurochirurgia · Università degli Studi di Napoli Federico II
Via Sergio Pansini 5
80131 Napoli
Italy
Phone: +39-81-746-2582
Fax: +39-81-746-2497
Email: cappabia@unina.it