RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000058.xml
Planta Med 2004; 70(3): 276-278
DOI: 10.1055/s-2004-818924
DOI: 10.1055/s-2004-818924
Letter
© Georg Thieme Verlag Stuttgart · New York
Antitubercular and Antiplasmodial Constituents of Abrus precatorius
We thank the Biodiversity Research and Training Program (BRT) and Faculty of Pharmacy (Silpakorn University) for financial supportWeitere Informationen
Publikationsverlauf
Received: September 18, 2003
Accepted: December 12, 2003
Publikationsdatum:
23. März 2004 (online)
Abstract
A known isoflavanquinone, abruquinone B (1), and a new derivative, abruquinone G (2), were isolated from the aerial parts of Abrus precatorius. Chemical structures of these compounds were elucidated by spectral analyses. While 1 exhibited antitubercular, antiplasmodial and cytotoxic activities, compound 2 showed mild antiviral and cytotoxic activities.
References
- 1 Chang L C. Chinese Material Medica Dictionary. Vol. 3 Chao-Jen Publisher Taichung; 1981: p 2299
- 2 Kuo S, Chen S, Chen L, Wu J, Wang J, Teng C. Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the roots of Abrus precatorius . Planta Med. 1995; 61 307-12
- 3 Alessandro L, Franco D, Giovanni Battista M, Deise Lia Barros C, Ivan Leoncio D. Abruquinones: new natural isoflavanquinones. Gazz Chem Ital. 1979; 109 9-12
- 4 Chiung-Yun C, Li-Jiau H, Jih-Pyang W, Che-Ming T, Sheng-Chih C, Sheng-Chu K. Synthesis and anti-platelet, anti-inflammatory and anti-allergic activities of methoxyisoflavanquinone and related compounds. Chem Pharm Bull. 2000; 48 964-73
- 5 Collins L, Franzblau S G. Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium . Antimicrob Agents Chemother. 1997; 41 1004-9
- 6 Skehan P, Stroreng R, Scudiero D, Monks A, McMahon J, Vestica D. et al . New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst. 1990; 82 1107-12
- 7 Trager W, Jensen J B. Human malaria parasites in continuous culture. Science. 1976; 193 673-5
- 8 Desjardins R E, Canfield C J, Haynes J D, Chulay J D. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother. 1979; 16 710-8
Dr. Chutima Limmatvapirat
Department of Pharmaceutical Chemistry
Faculty of Pharmacy
Silpakorn University
Nakorn-Pathom 73000
Thailand
Telefon: +66-34-255800 ext. 2125 or 2552
Fax: +66-34-255801
eMail: chutima@email.pharm.su.ac.th