New Triterpenoid Saponins from Bulbs of Bolbostemma paniculatum

Abstract

Nine new triterpenoid saponins were isolated from the bulbs of Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae): 7β,18,20,26-tetrahydroxy-(20S)-dammar-24E-en-3-O-α-L-(3-acetyl)arabinopyranosyl-(1→2)-β-D-glucopyranoside, 7β,18,20,26-tetrahydroxy-(20S)-dammar-24E-en-3-O-α-L-(4-acetyl)arabinopyranosyl-(1→2)-β-D-glucopyranoside, 7β,18,20,26-tetrahydroxy-(20S)-dammar-24E-en-3-O-α-L-arabinopyranosyl-(1→2)-β-D-(6-acetyl)glucopyranoside, 7β,20,26-trihydroxy-(20S)-dammar-24E-en-3-O-α-L-arabinopyranosyl-(1→2)-β-D-glucopyranoside, 7β,20,26-trihydroxy-(20S)-dammar-24E-en-3-O-α-L-(3-acetyl)arabinopyranosyl-(1→2)-β-D-glucopyranoside, 7β,20,26-trihydroxy-(20S)-dammar-24E-en-3-O-α-L-(4-acetyl)arabinopyranosyl-(1→2)-β-D-glucopyranoside, 7β,20,26-trihydroxy-8-formyl-(20S)-dammar-24E-en-3-O-α-L-(3-acetyl)arabinopyranosyl-(1→2)-β-D-glucopyranoside, 7β,20,26-trihydroxy-8-formyl-(20S)-dammar-24E-en-3-O-α-L-(4-acetyl)arabinopyranosyl-(1→2)-β-D-glucopyranoside and 6′-O-palmitoyltubeimoside I. In addition, four known triterpenoid saponins: tubeimoside I, tubeimoside II, tubeimoside III and tubeimoside IV were isolated. The structures of the above compounds were elucidated based on spectroscopic studies, and the configuration of C-20 of tubeimoside IV was revised as S rather than R as reported in previous literature. The compounds were tested for their antiviral activity

Bolbostemma paniculatum - Cucurbitaceae - triterpenoid saponins - dammarane triterpenes - antiviral activity

References

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