Download PDF
Am J Perinatol 2004; 21(2): 73-77
DOI: 10.1055/s-2004-820515
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA

Extended Interval Dosing of Gentamicin in Preterm Infants

Ma. Cecilia K. Mercado1 , Nancy L. Brodsky1 , 3 , Michael K. McGuire2 , Hallam Hurt1 , 3
  • 1Division of Neonatology, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, Pennsylvania
  • 2Department of Pharmacy, Albert Einstein Medical Center, Philadelphia, Pennsylvania
  • 3Current affiliation: Department of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Further Information

Publication History

Publication Date:
11 March 2004 (online)

Also available at
    Permissions and Reprints

Conventional interval dosing (CID) and extended interval dosing (EID) of gentamicin were compared in preterm infants. Gentamicin peak and trough levels, serum creatinine, urine output, and hearing screens were obtained in 40 preterm infants. Results suggest that EID is safe, provides gentamicin levels in desirable ranges (peak, 5 to 12 μg/mL; trough <2 μg/mL), and reduces dosage adjustments.

KEYWORDS

Gentamicin - dosing interval - preterm

REFERENCES

  • 1 Spivey J M. Clinical frontiers: the postantibiotic effect.  Clin Pharm. 1992;  11 865-875
    PubMedSearch in Google Scholar
  • 2 Skopnik H, Wallraf R, Nies B, Tröster K, Heimann G. Pharmacokinetics and antibacterial activity of daily gentamicin.  Arch Dis Child. 1992;  67 57-67
    PubMedSearch in Google Scholar
  • 3 Hayani K, Hatzopoulos F, Frank A et al.. Pharmacokinetics of once-daily dosing of gentamicin in neonates.  J Pediatr. 1997;  131 76-80
    PubMedSearch in Google Scholar
  • 4 Freeman C, Nicolau D, Belliveau P, Nightingale C. Once-daily dosing of aminoglycosides: review and recommendations for clinical practice.  J Antimicrob Chemother. 1997;  39 677-686
    CrossrefPubMedSearch in Google Scholar
  • 5 Elhanan K, Siplovich L, Raz R. Gentamicin once-daily versus thrice daily in children.  J Antimicrob Chemother. 1995;  35 327-332
    PubMedSearch in Google Scholar
  • 6 Skopnik H, Heimann G. Once-daily aminoglycoside dosing in full term neonates.  Pediatr Infect Dis J. 1995;  14 71-72
    PubMedSearch in Google Scholar
  • 7 Prober C G, Stevenson D K, Benitz W E. The use of antibiotics in neonates weighing less than 1200 grams.  Pediatr Infect Dis J. 1990;  9 111-121
    PubMedSearch in Google Scholar
  • 8 Reed M D, Besunder J B. Developmental pharmacology: ontogenic basis of drug disposition.  Pediatr Clin North Am. 1989;  36 1053-1074
    PubMedSearch in Google Scholar
  • 9 Murphy J E, Austin M L, Frye R F. Evaluation of gentamicin pharmacokinetics and dosing protocols in 195 neonates.  Am J Health Syst Pharm. 1998;  55 2280-2288
    PubMedSearch in Google Scholar
  • 10 Young T E, Mangum O B. NEOFAX A Manual of Drugs Used in Neonatal Care. 11th ed. Raleigh, NC; Acorn Publishing 1998: 32-33
    Search in Google Scholar
  • 11 de Alba Romero C, Castillo E, Secades C M, Lopez J R, Lopez L A, Valiente P S. Once daily gentamicin dosing in neonates.  Pediatr Infect Dis J. 1998;  17 1169-1171
    CrossrefPubMedSearch in Google Scholar
  • 12 Lundergan F S, Glasscock G F, Kim E H, Cohen R S. Once-daily gentamicin dosing in newborn infants.  Pediatrics. 1999;  103 1228-1234
    CrossrefPubMedSearch in Google Scholar
  • 13 Glover M L, Shaffer C L, Rubino C M et al.. A multicenter evaluation of gentamicin therapy in the neonatal intensive care unit.  Pharmacotherapy. 2001;  21 7-10
    CrossrefPubMedSearch in Google Scholar

Hallam HurtM.D. 

Children's Hospital of Philadelphia, Division of Neonatology

34th Street and Civic Center Blvd

Philadelphia, PA 19104