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Int J Sports Med 2005; 26(5): 356-362
DOI: 10.1055/s-2004-821158
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Oxygen Uptake Kinetics During Moderate and Heavy Intensity Exercise in Humans: The Influence of Hypoxia and Training Status

C. Cleuziou1 , S. Perrey2 , A. M. Lecoq3 , R. Candau2 , D. Courteix1 , P. Obert4
  • 1Laboratoire de Physiologie de l'Exercice Musculaire, Faculté des Sports et de l'Education Physique, Université d'Orléans, Orléans la Source, France
  • 2EA 2991, UFR STAPS, Université de Montpellier I, Montpellier, France
  • 3Département de Physiologie Respiratoire, Centre Hospitalier Régional d'Orléans, Orléans, France
  • 4Laboratoire des Adaptations Cardiovasculaires à l'Exercice, Faculté des Sciences, Université d'Avignon, Avignon, France
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Publication History

Accepted after revision: May 10, 2004

Publication Date:
10 September 2004 (online)

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Abstract

This study examined the influence of moderate hypoxia on the oxygen uptake (V·O2) kinetic response (primary time constant and slow component amplitude) during moderate and heavy cycle exercise in twenty-seven male subjects with various training status. Nine endurance trained (21.5 ± 2.6 yr), nine sprint trained (22.9 ± 5.7 yr), and nine untrained controls (24.0 ± 4.4 yr) completed incremental tests to exhaustion in normoxia (inspired gas concentration or FIO2 = 21 % O2) and hypoxia (FIO2 = 13 % O2) to establish the FIO2-specific ventilatory threshold (VT) and maximal VO2. Subsequently, the subjects performed repeated constant work rate cycling exercises during 7 min at moderate intensity (80 % of FIO2-specific VT) and heavy intensity (midway between the FIO2 specific VT and maximal VO2). Pulmonary gas exchange was measured breath-by-breath during all exercise sessions. For both moderate and heavy intensities, the time constant of the primary VO2 component was significantly (p < 0.05) slowed by ∼ 25 to 30 % in hypoxia compared to normoxia to the same extent in the three groups. Hypoxia produced a more important decrease in the amplitude of the slow component in endurance athletes (- 36 %) than in sprinters (- 30 %) and controls (- 12 %). These results suggest that both primary and slow components of VO2 kinetics during the adjustment to moderate- and heavy-intensity exercise are sensitive to hypoxia while training status tended to modulate partly the slow component amplitude.

Key words

Moderate hypoxia - oxygen uptake kinetics - slow component - training

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PhD S. Perrey

EA 2991 Motor Efficiency and Deficiency Laboratory, UFR STAPS

700 Avenue du Pic Saint Loup

34090 Montpellier I

France

Phone: + 33467415761

Fax: + 33 4 67 41 57 08

Email: stephane.perrey@univ-montpl.fr