A Simple One-Pot Synthesis of 2,6-Disubstituted 4-(Polyfluoroalkyl)pyridines and -pyrimidines by Reaction of 2-Polyfluoroalkylchromones with Aromatic Methyl Ketimines and Amidines

Vyacheslav Ya Sosnovskikh; Boris I. Usachev; Aleksei Yu Sizov; Mikhail A. Barabanov

doi:10.1055/s-2004-822321

PAPER

A Simple One-Pot Synthesis of 2,6-Disubstituted 4-(Polyfluoroalkyl)pyridines and -pyrimidines by Reaction of 2-Polyfluoroalkylchromones with Aromatic Methyl Ketimines and Amidines

Vyacheslav Ya. Sosnovskikh*, Boris I. Usachev, Aleksei Yu. Sizov, Mikhail A. Barabanov
Department of Chemistry, Ural State University, 620083 Ekaterinburg, Russian Federation
Fax: +7(3432)615978; e-Mail: Vyacheslav.Sosnovskikh@usu.ru;

Abstract

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Abstract

The reaction of 2-polyfluoroalkylchromones with ketimines, derived from aromatic methyl ketones and isopropylamine, gives 2,6-diaryl-4-polyfluoroalkylpyridines in moderate to low yields. Benzamidine and guanidine also react with 2-polyfluoroalkylchromones to afford the corresponding 2,6-disubstituted 4-polyfluoroalkylpyrimidines.

Key words

2-polyfluoroalkylchromones - ketimines - amidines - 4-polyfluoroalkylpyridines and -pyrimidines

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References

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