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Synthesis 2004(7): 1047-1051
DOI: 10.1055/s-2004-822331
DOI: 10.1055/s-2004-822331
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Highly Efficient Solvent-Free Synthesis of Dihydropyrimidinones Catalyzed by Zinc Chloride
Further Information
Received
9 January 2004
Publication Date:
02 April 2004 (online)
Publication History
Publication Date:
02 April 2004 (online)
Abstract
Dihydropyrimidinones are prepared from zinc chloride (20 mol%) catalyzed Biginelli condensation of an aldehyde, 1,3-dicarbonyl compounds and urea or thiourea at 80 °C for short time under solvent-free conditions in high yields.
Key words
Biginelli reaction - dihydropyrimidinones - zinc chloride - solvent-free - catalyst
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