LiClO4-Amine Mediated Direct Aldol Process

Morris Markert; Rainer Mahrwald

doi:10.1055/s-2004-822368

PAPER

LiClO₄-Amine Mediated Direct Aldol Process

Morris Markert, Rainer Mahrwald*
Institut für Chemie der Humboldt-Universität Berlin, Brook-Taylor Str. 2, 12 489 Berlin, Germany
Fax: +49(30)20936940; e-Mail: rainer.mahrwald@rz.hu-berlin.de;

Abstract

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Abstract

Aldol processes of aldehydes with secondary alcohols were observed by using a LiClO₄-amine reagent under very mild conditions. Unusual regio- and stereoselectivities observed during this new transformation are discussed. Stereotriades as well as stereopentades with configurations previously unattainable by aldol methodologies were isolated.

Key words

LiClO₄ - tertiary amines - aldehydes - secondary alcohols - aldol processes

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References

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