LiClO₄-Amine Mediated Direct Aldol Process

Abstract

Aldol processes of aldehydes with secondary alcohols were observed by using a LiClO₄-amine reagent under very mild conditions. Unusual regio- and stereoselectivities observed during this new transformation are discussed. Stereotriades as well as stereopentades with configurations previously unattainable by aldol methodologies were isolated.

Key words

LiClO₄ - tertiary amines - aldehydes - secondary alcohols - aldol processes

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The crystal structure of 7c has been deposited at the Cambridge Crystallographic Data Centre and has been allocated the deposition number CCDC 235882.