A Facile Synthesis of CD45 Protein Tyrosine Phosphatase Inhibitor Marine Natural Product Pulchellalactam

Sivaprakasam Mangaleswaran; Narshinha P. Argade

doi:10.1055/s-2004-822407

SHORTPAPER

A Facile Synthesis of CD45 Protein Tyrosine Phosphatase Inhibitor Marine Natural Product Pulchellalactam [1]

Sivaprakasam Mangaleswaran, Narshinha P. Argade*
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India
Fax: +91(20)25893153; e-Mail: argade@dalton.ncl.res.in;

Abstract

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Abstract

A facile five-step route to the naturally occurring CD45 protein tyrosine phosphatase inhibitor, (Z)-pulchellalactam, with 64% overall yield has been demonstrated starting from citraconimide (5) via regioselective NaBH₄ reduction, catalytic hydrogenation, resin-catalyzed dehydration, N-BOC protection, and stereoselective condensation pathway.

Key words

CD45 PTP inhibitor - pulchellalactam - citraconimide - two reductions - resin-catalyzed dehydration - synthesis

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Referenzen

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