Aktuelle- und Zukunftsaspekte zur Interaktion von Schwamm und Wunde in der Vakuumtherapie

Zusammenfassung

In diesem Beitrag werden aktueller Stand und Zukunftsperspektiven der Vakuumtherapie unter besonderer Berücksichtigung der verwendeten Materialien und deren Interaktionen mit der Wunde diskutiert.

Abstract

Tissue engineering research has demonstrated the potential of a variety of different matrix materials to enable cell adhesion, diffusion of nutrients, vascular ingrowth, nutrition and growth promotion. Therefore it appears attractive to apply these features also to topical negative pressure therapy. The article discusses several aspects of foam materials and their possible interactions with the wound surface.

Vakuum-Therapie - Schwamm-Materialien - Tissue engineering - Wundheilung

Vacuum therapy - sponge materials - tissue engineering - wound healing

Literatur

• 1 Dewey C FJ, Bussolari S R, Gimbrone M AJ, Davies P F. The dynamic response of vascular endothelial cells to fluid shear stress.  J Biomech Eng. 1981;  103 177-185
• 2 Winter G D. Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig.  Nature. 1962;  193 293-294
• 3 Vogt P M, Andree C, Breuing K. et al . Dry, moist, and wet skin wound repair.  Ann Plast Surg. 1995;  34 493-499
• 4 Langer R, Vacanti J P. Tissue engineering.  Science. 1993;  260 920-926
• 5 Sachlos E, Czermuszka T. Making tissue engineering scaffolds work. Review on the application of solid freeform fabrication technology to the production of tissue engineering scaffolds.  Europ Cells and Materials. 2003;  5 29-40
• 6 Fukuda J, Okamura K, Nakazawa K. et al . Efficacy of a polyurethane foam/spheroid artificial liver by using human hepatoblastoma cell line (Hep G2).  Cell Transplant. 2003;  12 51-58
• 7 Rennekampff H O, Kiessig V, Loomis W, Hansbrough J F. Growth peptide release from biologic dressings: a comparison.  J Burn Care Rehabil. 1996;  17 522-527
• 8 Lee J S, Cho Y S, Lee J W. et al . Preparation of wound dressing using hydrogel polyurethane foam.  Trends Biomater Artif Organs. 2002;  15 4-6
• 9 Li R H, White M, Williams S, Hazlett T. Poly(vinyl alcohol) synthetic polymer foams as scaffolds for cell encapsulation.  J Biomater Sci Polym Ed. 1998;  9 239-258
• 10 Wake M C, Mikos A G, Sarakinos G, Vacanti J P, Langer R. Dynamics of fibrovascular tissue ingrowth in hydrogel foams.  Cell Transplant. 1995;  4 275-279
• 11 Mutschler W, Burri C, Plank E. Experimental and clinical experiences with the synthetic skin cover of polyvinylalcohol-formaldehyde foam (PVA).  Helv Chir Acta. 1980;  47 163-166
• 12 Fleischmann W, Lang E, Kinzl L. Vacuum assisted wound closure after dermatofasciotomy of the lower extremity.  Unfallchirurg. 1996;  99 283-287
• 13 Morykwas M J, Argenta L C, Shelton-Brown E I, McGuirt W. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation.  Ann Plast Surg. 1997;  38 535-562