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Semin Reprod Med 2004; 22(1): 25-30
DOI: 10.1055/s-2004-823024
DOI: 10.1055/s-2004-823024
Models of Aromatase Insufficiency
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
13. April 2004 (online)
The recent studies on humans with a defective gene that encodes aromatase P450 (P450arom) and aromatase knockout (ArKO) mice with a disrupted P450arom gene uncovered many interesting aspects of physiology. Aromatase-deficient humans and ArKO mice continue to serve as invaluable models for us to study the roles of estrogen in normal and abnormal functions of several tissues. These roles will be discussed in detail in the following review article.
KEYWORDS
Aromatase deficiency - aromatase knockout mice - ArKO
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Professor
Evan R Simpson
Monash Medical Centre, Level 4, Block E, Prince Henry's Institute of Medical Research
P.O. Box 5152, 246 Clayton Road
Clayton, Victoria 3168 Australia