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Dtsch Med Wochenschr 2004; 129(15): 831-835
DOI: 10.1055/s-2004-823030
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Pharmakologie / Kardiologie
© Georg Thieme Verlag Stuttgart · New York

Genpolymorphismen in Arzneimittel-abbauenden Enzymen

Bedeutung für die Therapie mit β-BlockernGenetic polymorphisms in drug metabolizing enzymesImpact on treatment with β-blockersH. Wuttke1 , T. Rau1 , T. Eschenhagen1
  • 1Institut für Experimentelle und Klinische Pharmakologie, Universitätsklinikum Hamburg-Eppendorf
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Publikationsverlauf

eingereicht: 9.2.2004

akzeptiert: 18.3.2004

Publikationsdatum:
31. März 2004 (online)

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Glossar

CYP: Cytochrom P450

EM: Extensive metabolizer (normale metabolische Aktivität)

IM: Intermediate metabolizer (reduzierte metabolische Aktivität)

PM: Poor metabolizer (keine metabolische Aktivität)

UAW: Unerwünschte Arzneimittelwirkung

UM: Ultrarapid metabolizer (gesteigerte metabolische Aktivität)

Literatur

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Prof. Dr. med. Thomas Eschenhagen

Institut für Experimentelle und Klinische Pharmakologie, Universitätsklinikum Hamburg-Eppendorf

Martinistraße 52

20246 Hamburg

Telefon: +49/40/428033180

Fax: +49/40/428034876

eMail: t.eschenhagen@uke.uni-hamburg.de