Durch die Arzneimittelgesetzgebung des Jahres 2003 sind Medikamente, die den Kriterien der evidenz-basierten Medizin nicht entsprechen, nicht mehr verfügbar. Einschränkungen der Indikation haben die medikamentösen Behandlungsmöglichkeiten der Narkolepsie zusätzlich stark reduziert. Zur Beseitigung der Unsicherheit, die bei der Verordnung nicht mehr indizierter Präparate bestehen, wird ein Überblick über die im In- und Ausland erhältlichen Medikamente zur Behandlung von Tagesschläfrigkeit und Kataplexien gegeben.
Summary
Due to pharmaceutical legislation some drugs that did not meet the criteria of evidence based medicine were taken from the market in 2003. Restriction of indication caused further reduction fo narcolepsy medication. This caused some confusion in the medical community concerning prescription. To resolve the uncertainties this article gives an overview of the presently available drugs for treatment of excessive daytime sleepiness and cataplexies.
Literatur
1
Challman T D, Lipsky J J.
Methylphenidate: its pharmacology and uses.
Mayo Clin Proc.
2000;
75
711-721
2
Cook H. for the US Xyrem Multicenter Study Group .
A randomized, double blind, placebo-controlled multicenter trial comparing the effects of three doses of orallly administered sodium oxybate with placebo for the treatment of narcolepsy.
Sleep.
2002;
25
42-49
4
Engber T M, Koury E J, Dennis S A, Miller M S, Contreras P C, Bhat R V.
Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil.
Neuroscience Letter.
1998;
241
95-98
5
Ferraro L, Tanganelli S, O}Connor W T. et al .
The vigilance promoting drug modafinil decreases GABA release in the medial proptic area and in the posterior hypothalamus of the awake rat: possible involvement of the serotonergic 5-HT3 receptor.
Neurosci Lett.
1996;
220
5-8
7
Larrosa O, da la Llave Y, Bario S. et al .
Stimulant and anticataplectic effects of reboxetine in patients with narcolepsy: a pilot study.
Sleep.
2001;
24
282-285
9
Mitler M, Harsh J, Hirshkowitz M. et al .
Long-term efficacy and safety of modafinil for the treatment of excessive daytime sleepiness associated with narcolepsy.
Sleep Med.
2000;
14
53-60
11
Silber M H, Krahn L E, Olson E J, Pankratz V S.
The epidemiology of narcolepsy in Olmsted County, Minnesota: A population-based study.
Sleep.
2002;
2
197-204
13
US Modafinil in Narcolepsy Multicenter Study Group .
Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy.
Neurology.
2000;
54
1166-1175
14
Tanganellli S, Fuxe K, Ferraro L. et al .
Inhibitory effects of the psychoactive drug modafinil on gamma-aminobutyric acid outflow from the cerebral cortex of the awake freely moving giunea-pig. Possible involvement of 5-hydroxytryptamine mechanisms.
Haunyn Schmiedebergs Arch Pharmacol.
1992;
345
461-465
