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Synlett 2004(7): 1279-1281
DOI: 10.1055/s-2004-825593
DOI: 10.1055/s-2004-825593
LETTER
© Georg Thieme Verlag Stuttgart · New York
Asymmetric Iodocyclization of γ-Hydroxyalkenes
Further Information
Publication History
Received
12 March 2004
Publication Date:
10 May 2004 (online)


Abstract
Enantioselective intramolecular iodoetherification of disubstituted γ-hydroxyalkenes has been intended using NIS in the presence of 0.2 equivalents of (R)-Binol-Ti(IV) complex to procure the corresponding tetrahydrofurans in up to 65% ee.
Key words
reagent-controlled - iodocyclization - γ-hydroxyalkenes - (R)-Binol-Ti(IV) complex - N-iodosuccinimide