RSS-Feed abonnieren
DOI: 10.1055/s-2004-825830
Squamous Reepithelialization after Circumferential Endoscopic Mucosal Resection of Superficial Carcinoma Arising in Barrett’s Esophagus
Publikationsverlauf
Submitted 19 August 2003
Accepted after Revision 30 April 2004
Publikationsdatum:
28. September 2004 (online)
![](https://www.thieme-connect.de/media/endoscopy/200410/lookinside/thumbnails/10.1055-s-2004-825830-1.jpg)
Recent reports on the results of endoscopic ablation of Barrett’s mucosa have been promising, particularly when total mucosal ablation is coupled with aggressive acid-suppression treatment using high-dose proton-pump inhibitor therapy. There is also a considerable literature on reepithelialization after ablative treatments in Barrett’s esophagus. This report describes a case of multifocal superficial adenocarcinoma arising in Barrett’s mucosa that was successfully treated with total circumferential endoscopic mucosal resection, with a subsequent follow-up of more than 2 years. This is the first report describing the process of squamous reepithelialization after endoscopic mucosal resection in Barrett’s esophagus.
References
- 1 Gossner L, May A, Sroka R. et al . A new long-range through-the-scope balloon applicator for photodynamic therapy in the esophagus and cardia. Endoscopy. 1999; 31 370-376
- 2 Overholt B F. Acid suppression and reepithelialization after ablation of Barrett’s esophagus. Dig Dis. 2000-2001; 18 232-239
- 3 Takeshita K, Tani M, Inoue H. et al . Endoscopic treatment of early oesophageal carcinoma or gastric cancer. Gut. 1997; 40 123-127
- 4 Barr H, Shepherd N A, Dix A. et al . Eradication of high-grade dysplasia in columnar-lined (Barrett’s) oesophagus by photodynamic therapy with endogenously generated protoporphyrin 9. Lancet. 1996; 348 584-585
- 5 Satodate H, Inoue H, Yoshida T. et al . Circumferential endoscopic mucosal resection of carcinoma arising in Barrett’s esophagus: report of a case. Gastrointest Endosc. 2003; 58 288-292
- 6 Schlemper R, Dawsey S, Itabashi M. et al . Differences in diagnostic criteria for esophageal squamous carcinomas between Japanese and Western pathologists. Cancer. 2000; 88 996-1006
- 7 Bremner C G, Lynch V P, Ellis F H. Barrett’s esophagus: congenital or acquired? An experimental study of esophageal mucosal regeneration in the dog. Surgery. 1970; 68 209-216
- 8 Sampliner R E, Hixon L J, Fennerty M B. et al . Regression of Barrett’s esophagus by laser ablation in an antacid environment. Dig Dis Sci. 1993; 38 365-368
- 9 Ertan A, Zimmerman M, Younes M. Esophageal adenocarcinoma associated with Barrett’s esophagus: long-term management with laser ablation. Am J Gastroenterol. 1995; 90 2201-2203
- 10 Gossner L, May A, Stolte M. et al . KTP laser destruction of dysplasia and early cancer in columnar-lined Barrett’s esophagus. Gastrointest Endosc. 1999; 49 8-12
- 11 Sampliner R E, Fass R. Partial regression of Barrett’s esophagus: an inadequate endpoint. Am J Gastroenterol. 1993; 88 2092-2094
- 12 Bremner R M, Mason R J, Bremner C G. Ultrasonic epithelial ablation of the lower esophagus without stricture formation: a new technique for Barrett’s ablation. Surg Endosc. 1998; 12 342-347
- 13 Inoue H, Takeshita K, Hori H. et al . Endoscopic mucosal resection with a cap-fitted panendoscope for esophagus, stomach, and colon mucosal lesions. Gastrointest Endosc. 1993; 39 58-62
- 14 May A, Gossner L, Pech O. et al . Local endoscopic therapy for intraepithelial high-grade neoplasia and early adenocarcinoma in Barrett’s esophagus: acute-phase and long-term results of new treatment approach. Eur J Gastroenterol Hepatol. 2002; 14 1085-1091
- 15 Biddlestone L R, Barham C P, Wilkinson S P. et al . The histopathology of treated Barrett’s esophagus: squamous reepithelialization after acid suppression and laser and photodynamic therapy. Am J Surg Pathol. 1998; 22 239-245
- 16 Inoue H, Maruyama M, Takeshita K. et al . Healing process of the artificial ulcer induced by endoscopic esophageal mucosal resection [in Japanese with English abstract]. Gastroenterol Endosc. 1991; 33 711-714
H. Satodate, M. D.
Digestive Disease Center
Showa University Northern Yokohama Hospital · 35-1 Chigasaki-chuo, Tsuzuki-ku · Yokohama 224-8503 · Japan
Fax: + 81-45-949-7927 ·
eMail: hitoshi-satodate@nifty.com