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Intensivmedizin up2date 2005; 1(1): 9-20
DOI: 10.1055/s-2004-826111
Allgemeine Prinzipien der Intensivmedizin
© Georg Thieme Verlag KG Stuttgart · New York

Pathophysiologie der Sepsis (mit Videos)

Andreas  Sielenkämper,, Lars  Fischer, Hendrik  Freise, Hugo  Van Aken
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Publication History

Publication Date:
05 July 2006 (online)

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Kernaussagen
Sepsis ist die systemische Reaktion auf eine Infektion, wobei als zentrale Komponenten dieser Reaktion Entzündungsmechanismen, Gerinnungsaktivierung, Endotheldysfunktion und Mikrozirkulationsschaden in Wechselwirkung treten.
Resultat ist in vielen Fällen eine vitale Bedrohung des Organismus durch Multiorgandysfunktion und -versagen.
Der Kenntnisstand über die zentralen Pathomechanismen der Sepsis ist in den letzten Jahren enorm gewachsen. Neue, aus diesem Wissen heraus abgeleitete Therapieansätze erbrachten im Rahmen klinischer Studien nur begrenzte Therapieerfolge, ohne die hohe Letalität bei Sepsis entscheidend zu senken.

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Priv.-Doz. Dr. A. Sielenkämper

Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin · Universitätsklinikum Münster

Albert-Schweitzer-Str. 33 · 48129 Münster

Phone: 0251 8347255

Fax: 0251 8348667

Email: sieland@uni-muenster.de