Structure of Kaurane-Type Diterpenes from Parinari sprucei and their Potential Anticancer Activity

Abstract

Twenty-three kaurane-type diterpenes 1 - 23, including twenty new natural products 1 - 20, have been isolated from the leaves of Parinari sprucei and their structures elucidated by spectroscopic and chemical analysis. The isolated compounds were tested for their cytotoxic activity towards a panel of cancer cell lines. Compounds 9 and 10 showed activity against all cell lines with ED₅₀ values in the range of 10 - 20 μg/mL. The previously known 13-hydroxy-15-oxozoapatlin 21 was evaluated in an in vivo hollow fiber test, and found to be active with KB and LNCaP cells at the concentrations used.

Parinari sprucei - Chrysobalanaceae - leaves - kaurane diterpenes - cytotoxicity - hollow fiber test

References

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